【Objective】 To study the effects of fruit set height on cluster micro-environment,fruit quality and wine quality of wine grape under ‘M-VSP’ in extreme arid region in the hope of providing a reference for the improvement of raw material quality of aging wine grape and the selection of suitable fruit set height for standardized cultivation of ‘M-VSP’ cultivation in this kind of environment. 【Methods】 Different fruit set height（40 cm,60 cm,80 cm and 100 cm）of 6 years old wine Cabernet Sauvignon grapes were taken as experiment materials to analyze the cluster microenvironment, fruit development, fruit quality and wine quality of different fruit set heights. 【Results】 Cluster microdomain temperature, humidity and PAR were different in different fruit set heights during the growth stage of wine grape, average temperature of 40cm was 0.84℃（2.77%） and 0.73℃（2.42%） lower than 80cm and 100cm respectively,temperature difference sum and heat hours of 40 cm exceed 35℃ decreased by 7.58 %,13.39 % and 10.54 %,13.87 % respectively compared with 80 cm and 100 cm,average humidity of cluster microdomain of 40 cm and 60 cm were increased by 8.86 %,4.90 % and 15.40%,11.21% compared with 80 cm and 100 cm. The temperature from noon to night of 40cm was the minimum, but humidity of all day was higher than others,PAR of 40 cm was decreased by 20.81 %,21.85 % and 37.95 % compare with 60 cm,80 cm and 100 cm,and PAR of 40 cm the whole day was the minimum. The higher bearing height,the smaller berry weight and berry volume and the higher degree of wilting at later fruit development,so sugar,acid and some phenols began to concentrate. Cluster weight was decreased along with bearing height increase,cluster weight and berry weight of 100 cm and 80 cm were decreased by 45.38 %,20.75 % and 16.67%,10.78 % compared with 40 cm. Cluster of 40 cm was moderation,wilting percent decreased by 91.41 % and 76.87 %,seed coat color and skin color value was relatively low. Reducing sugar mass concentration and total phenols of 40 cm was decreased by 6.32 %,8.76 %,13.35 % and 6.84 %,13.02 % and 8.63 % compared with 60 cm,80 cm and 100 cm respectively,total acid mass concentration of 40 cm was increased by 6.46 % compared with 60 cm and 80 cm,alcohol content and anthocyanins content of 40 cm were relatively low,however acid and tannins were higher. 【Conclusion】 ‘M-VSP’of 40 cm can effectively improve cluster microenvironment,slow down flucose accumulation speed,remain high acid,enhance phenolic content,thus improving the quality of wine grapes and wines.