石榴皮瓤提取物对成年小鼠体重增长及血浆免疫相关指标的影响

doi:10.6048/j.issn.1001-4330.2023.08.030

新疆农业科学 ›› 2023, Vol. 60 ›› Issue (8): 2074-2080.DOI: 10.6048/j.issn.1001-4330.2023.08.030

• 草业·畜牧兽医 • 上一篇

石榴皮瓤提取物对成年小鼠体重增长及血浆免疫相关指标的影响

刘佳佳¹(), 韩涛²()

1.新疆畜牧科学院畜牧研究所,乌鲁木齐 830011
2.新疆畜牧科学院兽医研究所,乌鲁木齐 830011

收稿日期:2022-11-05 出版日期:2023-08-20 发布日期:2023-08-14
通信作者: 韩涛(1980-),男,河南信阳人,副研究员,研究方向为畜牧与动物医学,(E-mail)172387243@qq.com
作者简介:刘佳佳(1986-),男,河南济源人,副研究员,研究方向为动物营养与饲料科学,(E-mail)462059537@qq.com
基金资助:
新疆维吾尔自治区重点研发计划项目“肉鸽产业提质增效关键技术集成与示范”(2020B01007-2)

Effect of pomegranate peel flesh extract on body weight gain and plasma Immunity-related indexes in adult mice

LIU Jiajia¹(), HAN Tao²()

1. Institute of Animal Husbandry, Xinjiang Academy of Animal Sciences, Urumqi 830011,China
2. Institute of Veterinary Medicine, Xinjiang Academy of Animal Sciences, Urumqi 830011,China

Received:2022-11-05 Online:2023-08-20 Published:2023-08-14
Correspondence author: HAN Tao (1980-), male, Xinyang, Henan, Associate researcher, research direction is animal husbandry and animal medicine, (E-mail)172387243@qq.com
Supported by:
Xinjiang Uygur Autonomous Region key R&D plan project "Integration and demonstration of key technologies for improving quality and increasing efficiency of meat pigeon industry"(2020B01007-2)

摘要/Abstract

摘要：

【目的】研究石榴皮瓤提取物对小鼠体重、血浆抗氧化和促炎因子水平的影响。【方法】选择平均体重(37.31±5.57) g的成年小鼠30只,随机分为2组,每组15只,分别为对照组和试验组。在相同基础日粮条件下试验组小鼠灌喂1.5 g/(d·只)石榴皮瓤粗提物[即鞣花酸的灌喂量为40.74 mg/(d·只)],对照组小鼠灌喂相应体积的无菌蒸馏水,灌喂试验21 d。试验结束当天,小鼠晨饲前空腹称量体重,断尾采集小鼠血液。【结果】(1)试验组小鼠的末重、总增重和平均日增重分别比对照组显著提高了8.21%(P<0.05)、47.56%(P<0.05)和48.39%(P<0.05);(2)试验组小鼠血浆中SOD、CAT、和T-AOC水平分别比对照组显著提高了24.44%(P<0.05)、54.82%(P<0.05)和27.69%(P<0.05),抑制羟自由基能力和抗超氧阴离子活力分别比对照组极显著提高了36.01%(P<0.01)和43.21%(P<0.01),显著降低了试验组小鼠血浆中MAD的浓度(P<0.05);(3)试验组小鼠血浆中TNF-α和IL-17分别比对照组显著降低了17.16%(P<0.05)和30.34%(P<0.05)。【结论】对小鼠灌喂石榴皮瓤提取物可显著增加小鼠体重,提高小鼠抗氧化能力和抗炎症能力。

关键词: 石榴皮瓤提取物; 小鼠; 体重; 抗氧化; 炎症

Abstract:

【Objective】 This experiment aims to investigate the effects of pomegranate peel flesh extract on body weight, plasma antioxidant and pro-inflammatory factor levels in mice in the hope of providing a theoretical basis for further research on the biological effects of pomegranate peel flesh extract.【Methods】 Thirty adult male mice with an average body weight of (37.31±5.57) g were randomly divided into 2 groups: the control group and the test group, with 5 replicates of 3 mice in each group, for a total of 15 mice.Mice in the test group were fed 1.5 g/(d-animal) of crude extract of pomegranate peel flesh [i.e., ellagic acid at 40.74 mg/(d-animal)] under the same basal diet, and mice in the control group were fed the corresponding quantity of sterile distilled water for 21 days.At the end of the experiment, mice were weighed on an empty stomach before morning feeding, and blood was collected from the mice with their tails severed.【Results】 The results showed that (1) the end weight, total weight gain and mean daily weight gain of mice in the test group were significantly increased by 8.21% (P<0.05), 47.56% (P<0.05) and 48.39% (P<0.05), respectively, compared with the control group; (2) the plasma levels of SOD, CAT, and T-AOC in mice in the test group were significantly increased by 24.44% (P< 0.05), 54.82% (P<0.05), and 27.69% (P<0.05), respectively, and the ability to inhibit hydroxyl radicals and anti-superoxide anion activity were highly significantly increased by 36.01% (P<0.01) and 43.21% (P<0.01), respectively, compared with the control group, which significantly reduced the concentration of MAD in the plasma of mice in the test group (P<0.05); (3) the plasma levels of TNF mice plasma TNF-α and IL-17 were significantly reduced by 17.16% (P<0.05) and 30.34% (P<0.05), respectively, compared with the control group.【Conclusion】 In conclusion, under the present experimental conditions, the administration of pomegranate peel flesh extract to mice significantly increases their body weight and improves their antioxidant capacity and anti-inflammatory ability.

Key words: pomegranate peel flesh extract; mice; body weight; antioxidant; inflammation

中图分类号:

S852

刘佳佳, 韩涛. 石榴皮瓤提取物对成年小鼠体重增长及血浆免疫相关指标的影响[J]. 新疆农业科学, 2023, 60(8): 2074-2080.

LIU Jiajia, HAN Tao. Effect of pomegranate peel flesh extract on body weight gain and plasma Immunity-related indexes in adult mice[J]. Xinjiang Agricultural Sciences, 2023, 60(8): 2074-2080.

图/表 5

参考文献 37

[1]	赵甜甜, 寇忠云, 庞卫军. 中草药提取物替代抗生素在猪精液常温保存中的应用研究进展[J]. 养猪, 2021,(5):38-42.
	ZHAO Tiantian, KOU Zhongyun, PANG Weijun. Research Progress in the Application of Chinese Herbal Extracts as An Alternative to Antibiotics During Liquid Preservation at 17℃[J]. Swine Production, 2021,(5): 38-42.
[2]	Mirzaeiaghsaghali A, Maherisis N, Mansouri H, et al. Evaluating Potential Nutritive Value of Pomegranate Processing By-Products For Ruminants Using in Vitro Gas Production Technique[J]. Journal of Agricultural & Biological Science, 2011.
[3]	Amor A J, Gómez Guerrero C, Ortega E, et al. Ellagic Acid as a Tool to Limit the Diabetes Burden: Updated Evidence[J]. Antioxidants (Basel, Switzerland), 9(12):1226. DOI URL
[4]	Hama, Khan, Karwan, et al. Changes in lipid profile and some blood biochemical parameters in Karadi lambs receiving different levels of pomegranate peels[J]. Research Opinions in Animal & Veterinary Sciences, 2015.
[5]	Wang Q, Kim H J, Cho J H, et al. Effects of phytogenic substances on growth performance, digestibility of nutrients, faecal noxious gas content, blood and milk characteristics and reproduction in sows and litter performance[J]. Canadian Journal of Economics & Political Science/revue Canadienne De Economiques Et Science Politique, 2008, 17(1):362-378.
[6]	陈鹏, 涂晶晶, 李巧玲, 等. 肠道菌群对石榴皮鞣质的分解代谢作用研究[J]. 中草药, 2019, 50 (14): 3396-3402.
	CHEN Peng, TU Jingjing, LI Qiaoling, et al. Study of metabolism of tannins from Granati Pericarpium in intestinal flora[J]. Chinese Traditional and Herbal Drugs, 2019, 50(14): 3396-3402.
[7]	肖玉欣, 王楠, 王婧, 等. 鞣花酸和尿石素类代谢产物的生物活性及其对肠道健康的积极作用[J/OL]. 食品科学: 1-14 [2021-10-21].
	XIAO Yuxin, WANG Nan, WANG Jing, et al. Bioactivities of Ellagic Acid and Urolithins and their Benefits to Gut Health[J/OL]. Food Science: 1-14 [2021-10-21].
[8]	Cerdá B, Tomás-barbeán F A, Espín J C. Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability[J]. J Agric Food Chem, 2005, 53(2): 227-235. DOI URL
[9]	Rahimi V B, Ghadiri M, Ramezani M, et al. Anti-inflammatory and anti-cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies[J]. Phytother Res, 2020, 34(4): 685-720.
[10]	张华, 陈虹, 杨丹, 等. 鞣花酸大鼠在体肠吸收研究[J]. 中国医院药学杂志, 2014, 34(14): 1167-1170.
	ZHANG Hua, CHEN Hong, CHEN Dan, et al. In situ intestinal absorption of ellagic acid in rats[J]. Chinese Journal of Hospital Pharmacy, 2014, 34(14): 1167-1170.
[11]	畅静. 新疆石榴皮多酚抗肿瘤有效部位及其主要成分的胃肠道吸收特性研究[D]. 乌鲁木齐: 新疆医科大学, 2015.
	CHANG Jing. To study the gastrointestinal absorption characteristics of the Xinjiang pomegranate peel polyphenols’ purification main components and effctive parts of the main anti-tumor[D]. Urumqi: Xinjiang Medical University, 2015.
[12]	赵铭伟, 奉玲丽, 张琰芳, 等. 鞣花酸对断奶仔猪小肠黏膜形态及肠黏膜屏障功能的影响[J]. 黑龙江畜牧兽医, 2020, (21): 126-130,135,177.
	ZHAO Mingwei, FENG Lingli, ZHANG Yanfang, et al. Study on the adaptability of different species of Petrel in Gongzhuling area[J]. Heilongjiang Animal Science and Veterinary Medicine, 2020, (21): 126-130,135,177.
[13]	陈晖, 李佳豪, 李超, 等. 灌喂石榴汁对大鼠体重及粪便和盲肠中鞣花酸、尿石素A含量的影响[J]. 畜牧与饲料科学, 2019, 40 (7): 11-14.
	CHEN Hui, LI Jiahui, LI Chao, et al. Effects of Pomegranate Juice on Body Weight and Content of Ellagic Acid and Urolithin A in Feces and Cecum Contents in Rats[J]. Animal Husbandry and Feed Science, 2019, 40 (7): 11-14.
[14]	陈杰. 家畜生理学(第四版)[M]. 北京: 中国农业出版社, 2003.
	CHEN J. Livestock physiology (4th Ed.)[M]. Beijing: China Agricultural Press, 2003.
[15]	赵芳, 陈学济, 李晓斌, 等. 补喂ã-氨基丁酸对哺乳期马驹血浆生化指标及免疫球蛋白含量的影响[J]. 新疆农业科学, 2016, 53(5): 974-980.
	ZHAO Fang, CHEN Xueji, LI Xiaobin, et al. Effects of Supplementary GABA on the Concentration of Blood Biochemical Index and Immunoglobulin in Nursing Ili Foals Plasma[J]. Xinjiang Agricultural Sciences, 2016, 53(5):974-980.
[16]	周本宏, 凃杰, 刘苗苗, 等. 石榴皮鞣质对慢性肾小球肾炎的改善作用[J]. 中国医院药学杂志, 2013, 33(21): 1739-1743.
	ZHOU Benhong, TU Jie, LIU Miaomiao, et al. Improving effect of tannins in Pomegranate rind on chronic glomerulonephritis[J]. Chinese Journal of Hospital Pharmacy, 2013, 33(21): 1739-1743.
[17]	Stanluy C C, Williams C C, Jenny B F, et al. Effects of Feeding Milk Replacer Once Versus Twice Daily on Glucose Metabolism in Holstein and Jersey Calves[J]. Journal of Dairy Science, 2002, 85(9): 2335-2343. DOI PMID
[18]	苏鹏程. 不同代谢葡萄糖水平日粮条件下白绒山羊体内蛋白质(氨基酸)分配规律的研究[D]. 呼和浩特: 内蒙古农业大学, 2004.
	SU Pengcheng. Study on Partitioning of Proteins (Amino Acids) in White Cashmere Goats Fed Diets with Different Dietary Metabolizable Glucose Levels[D]. Hohhot: Inner Mongolia Agricultural University, 2004.
[19]	Coma J, Carrion D, Zimmerman D R. Use of plasma urea nitrogen as a rapid response criterion to hetennine the lysine requirement of pigs[J]. Journal of Animal Science (USA), 1995, 73(2):472-481. DOI PMID
[20]	Torrallardona D, Conde R, Esteve-Garca E, et al. Use of spray dried animal plasma as an alternative to antimicrobial medication in weanling pigs[J]. Animal Feed Science & Technology, 2002, 99 (1): 119-129.
[21]	Hduson M B, Hosick P A, Mccaulley G O, et al. The Effect of resistance exercise on humoral markers of oxidative stress[J]. Medicine & Science in Sports & Exercise, 2008, 40(3):542-548.
[22]	Qiu Z, Zhou B, Jin L, et al. In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells[J]. Food and Chemical Toxicology, 2013, 59: 428-437. DOI PMID
[23]	骆静方, 魏巍, 乔楠, 等. 鞣花酸对四氧嘧啶糖尿病小鼠的影响[J]. 中国糖尿病杂志, 2016, 24(7): 649-651.
	LUO Jingfang, WEI Wei, QIAO Nan, et al. Effect of ellagic acid on Alloxan-induced diabetes in mice[J]. Chinese Journal of Diabetes, 2016, 24(7): 649-651.
[24]	陈敏纯, 张婧一, 张雨晨, 等. 鞣花酸对缺血性脑卒中大鼠的保护作用[J]. 中成药, 2021, 43 (9): 2331-2335.
	CHEN Minchun, ZHANG Jingyi, ZHANG Yuchen, et al. Benifits of ellagic acid for rats with cerebral ischemic stroke[J]. Chinese Traditional Patent Medicine, 2021, 43(9): 2331-2335.
[25]	黄新新, 朱静, 李璇玥, 等. 灌喂石榴皮瓤提取物对小鼠盲肠菌群结构及多样性的影响[J]. 饲料工业, 2021, 42 (3): 25-31.
	HUANG Xinxin, ZHU Jing, LI Xuanyue, et al. Effects of Pomegranate Skin Extract on the Structure and Diversity of Mouse Cecum Microbiota[J]. Feed Industry, 2021, 42 (3): 25-31.
[26]	Cerdá B, Periago P, Espín J C, et al. Identification of urolithin A as a metabolite produced by human colon microflora from ellagic acid and related compounds[J]. Journal of Agricultural and Food Chemistry, 2005, 53 (14): 5571-5576. DOI PMID
[27]	古丽海夏·哈勒玛合拜, 田亚丽, 巴合提别克·托合塔尔拜克, 等. 鞣花酸对糖尿病小鼠胰腺炎的改善作用[J]. 中成药, 2020, 42(3):744-747.
	Gulihaixia Halemahebai, TIAN Yali, Bahetibieke Tuohetaerbaike, et al. Ameliorative effect of ellagic acid on pancreatitis in diabetic mice[J]. Chinese Traditional Patent Medicine, 2020, 42(3):744-747.
[28]	García-Villalba, Rocío, D Beltrán, J C Espín, et al. Time Course Production of Urolithins from Ellagic Acid by Human Gut Microbiota[J]. Journal of Agricultural and Food Chemistry, 2013, 61(37): 8797. DOI PMID
[29]	Larrosa M, Antonio González-Sarrías, María J.Yáez-Gascón, et al. Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism[J]. Journal of Nutritional Biochemistry, 2010, 21(8): 717-725. DOI PMID
[30]	Shida M, Kitajima Y, Nakamura J, et al. Impaired mitophagy activates mtROS/HIF-1á interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia[J]. International journal of oncology, 2016. 48 (4): 1379-1390. DOI URL
[31]	Ryu D, Mouchiroud L, Andreux P A, et al. Urolithin A induces mitophagy and prolongs lifespan in C.elegans and increases muscle function in rodents[J]. Nature Medicine, 2016. 22 (8): 879-888. DOI
[32]	缪福俊, 宁德鲁. 核桃多酚类物质生物活性研究进展[J]. 中国油脂, 2021, 46 (1): 48-51.
	MIU Fujun, NING Delu. Progress on bioactivity of walnut polyphones[J]. China Oils and Fats, 2021, 46 (1): 48-51.
[33]	Marín M, Giner R M, Ríos J-L, et al. Intestinal anti-inflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis[J]. Journal of Ethno Pharmacology, 2013. 150(3): 925-934.
[34]	Giménez-Bastida, Truchado P, Larrosa M, et al. Urolithins, ellagitannin metabolites produced by colon microbiota, inhibit Quorum Sensing in Yersinia enterocolitica: Phenotypic response and associated molecular changes[J]. Food Chemistry, 2012, 132 (3): 1465-1474. DOI PMID
[35]	Singh R, Chandrashekharappa S, Bodduluri S R, et al. Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway[J]. Nature Communications, 2019, 10(1).
[36]	王佳俊, 陈青垚, 王建, 等. 基于数据挖掘和网络药理学探究含黄连方剂治疗溃疡性结肠炎的配伍规律及作用机制[J]. 中草药, 2021, 52 (19): 5984-5995.
	WANG Jiajun, CHEN Qingyao, WANG Jian, et al. Compatibility regularity and mechanism of prescriptions containing Coptidis Rhizoma in treatment of ulcerative colitis based on data mining and network pharmacology[J]. Chinese Traditional and Herbal Drugs, 2021, 52(19): 5984-5995.
[37]	JA Giménez-Bastida, A González-Sarrías, Larrosa M, et al. Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-á-induced inflammation and associated molecular markers in human aortic endothelial cells[J]. Molecular Nutrition & Food Research, 2012.

原料 Ingredients	比例 Proportion	营养水平 Nutrition level	含量 Content
小麦粉Wheat flour	35.00	干物质DM	93.48
玉米Corn	20.00	有机物OM	91.67
豆粕Bean pulp	23.00	粗蛋白质CP	15.56
鱼粉Fish Meal	8.00	中性洗涤纤维NDF	17.95
葵饼Sunflower cake	8.00	酸性洗涤纤维ADF	7.50
肉骨粉 Meat and bone powder	4.00	钙Ca	1.69
食盐NaCl	1.00	磷P	0.12
磷酸氢钙CaHPO₄	0.50
石粉Limestone	0.48
多种维生素预混料 Premix¹⁾	0.02
合计Total	100

原料 Ingredients	比例 Proportion	营养水平 Nutrition level	含量 Content
小麦粉Wheat flour	35.00	干物质DM	93.48
玉米Corn	20.00	有机物OM	91.67
豆粕Bean pulp	23.00	粗蛋白质CP	15.56
鱼粉Fish Meal	8.00	中性洗涤纤维NDF	17.95
葵饼Sunflower cake	8.00	酸性洗涤纤维ADF	7.50
肉骨粉 Meat and bone powder	4.00	钙Ca	1.69
食盐NaCl	1.00	磷P	0.12
磷酸氢钙CaHPO₄	0.50
石粉Limestone	0.48
多种维生素预混料 Premix¹⁾	0.02
合计Total	100

项目 Items	对照组 Control Group	试验组 Trial Group	P值 P-value
日均采食量 Average daily feed intake(g)	5.12±0.14	5.36±0.21	0.121
初始重 Original weight(g)	37.08±4.09	37.53±6.17	0.813
末重 Final weight(g)	43.63±4.87^b	47.21±3.95^a	0.041
总增重 Total weight(g)	6.56±3.07^b	9.68±4.54^a	0.046
日增重 Average daily gain (g/day)	0.31±0.15^b	0.46±0.22^a	0.046

项目 Items	对照组 Control Group	试验组 Trial Group	P值 P-value
日均采食量 Average daily feed intake(g)	5.12±0.14	5.36±0.21	0.121
初始重 Original weight(g)	37.08±4.09	37.53±6.17	0.813
末重 Final weight(g)	43.63±4.87^b	47.21±3.95^a	0.041
总增重 Total weight(g)	6.56±3.07^b	9.68±4.54^a	0.046
日增重 Average daily gain (g/day)	0.31±0.15^b	0.46±0.22^a	0.046

项目 Items	对照组 Control Group	试验组 Trial Group	P值 P-value
总蛋白 TP (g/L)	47.84±3.20	51.06±2.687	0.123
白蛋白 ALB (g/)L	23.81±0.89	25.57±1.75	0.123
球蛋白 GLB (g/L)	24.03±0.56	25.49±2.11	0.126
尿素氮 BUN (mmol/L)	4.42±1.34	2.94±0.72	0.089

石榴皮瓤提取物对成年小鼠体重增长及血浆免疫相关指标的影响

Effect of pomegranate peel flesh extract on body weight gain and plasma Immunity-related indexes in adult mice

在线阅读

PDF下载

可视化

摘要/Abstract

引用本文

使用本文

图/表 5

参考文献 37

相关文章 15

编辑推荐

Metrics

项目 Items	对照组 Control Group	试验组 Trial Group	P值 P-value
超氧化物歧化酶 SOD(U/mL)	138.83±18.21^b	172.76±14.47^a	0.019
过氧化氢酶 CAT(U/mL)	3.32±0.76^b	5.14±1.15^a	0.019
谷胱甘肽氧化物酶 GSH-PX(U/mL)	658.44±41.10	689.32±89.73	0.511
抑制羟自由基能力 (U/mL)	483.66±58.73^B	657.83±39.34^A	0.001
抗超氧阴离子活力 (U/L)	414.94±71.83^B	594.23±46.29^A	0.004
总抗氧化能力 T-AOC (mmol/L)	0.65±0.09^b	0.83±0.09^a	0.027
一氧化氮 NO (μmol/L)	33.51±3.07	37.34±6.83	0.294
丙二醛 MDA (nmol/mL)	5.81±1.06^a	4.31±0.45^b	0.033

项目 Items	对照组 Control Group	试验组 Trial Group	P值 P-value
肿瘤坏死因子 TNF-α(pg/mL)	11.25±1.77^a	9.32±0.45^b	0.031
白细胞介素-17 IL-17A(pg/mL)	5.67±1.89^a	3.95±0.16^b	0.048
白细胞介素-10 IL-10(pg/mL)	6.61±0.99	5.18±0.89	0.050

[1]	柏玲, 冯国郡, 胡相伟, 赵云, 石书兵. 不同谷子品种萌发期抗旱鉴定及生理变化[J]. 新疆农业科学, 2023, 60(7): 1630-1640.
[2]	杨帆, 李晓斌, 陈开旭, 黄新新, 马晨, 肖海霞, 阿不来提·苏来曼, 解鹏. 补饲精料补充料对育肥驴体重增加、血液生化指标影响[J]. 新疆农业科学, 2023, 60(6): 1548-1554.
[3]	陈丽靓, 鲁倩君, 马媛媛, 刘迎, 赵宝龙, 孙军利. 不同葡萄品种的耐盐性比较分析[J]. 新疆农业科学, 2023, 60(4): 880-888.
[4]	李爽, 谢丹露, 吴继周, 马瑞, 谢艾迪, 邵蕾, 高娟娟, 韩海霞. 不同炮制方法下若羌灰枣主要功能成分及抗氧化活性的对比[J]. 新疆农业科学, 2023, 60(4): 935-942.
[5]	裴红霞, 李生梅, 武旭霞, 耿世伟, 赖黎丽, 高晶霞, 董心久. 辣椒核雄性不育系pby-1形态学及生理生化特性分析[J]. 新疆农业科学, 2023, 60(3): 624-632.
[6]	祖力皮牙·买买提, 毛红艳, 岳丽, 王佳敏, 于明. 三色藜麦抗氧化活性及体外消化特性[J]. 新疆农业科学, 2023, 60(10): 2461-2469.
[7]	郑子漂, 徐海江, 崔建平, 林涛, 郭仁松, 王亮, 张大伟, 魏鑫, 孔繁阳. 水分胁迫对陆地棉生长发育的影响[J]. 新疆农业科学, 2022, 59(8): 1821-1830.
[8]	韩海霞, 游林, 钟志明, 何梦梦, 王娜, 李爽. 肉苁蓉浸膏制备中温度对苯乙醇苷类成分的影响及其抗氧化活性分析[J]. 新疆农业科学, 2022, 59(8): 1975-1983.
[9]	李超, 李晓斌, 邓海峰, 黄新新, 杨帆, 李海, 陈开旭. 0~12月龄纯血马驹体重、体尺增长的变化分析[J]. 新疆农业科学, 2022, 59(6): 1545-1552.
[10]	刘志刚, 任红松, 胡西旦·买买提, 王瑞华, 李海峰, 胡国智. 高温期喷施外源钙对甜瓜幼苗叶片生理特性的影响[J]. 新疆农业科学, 2022, 59(3): 588-596.
[11]	蔡鹏, 孙小燕, 阿迪莱·艾力, 雷艳, 单宝轩, 赵红琼. 荨麻皮刺水提液对小鼠离体肠平滑肌运动的影响[J]. 新疆农业科学, 2022, 59(3): 767-773.
[12]	吴睿宸, 姚新奎, 孟军, 曾亚琦, 王川坤, 阿拉法特·艾合买提, 努尔塔依·库尔班塔依. 补饲不同剂量竹叶提取物对泌乳期伊犁马血液生化指标的影响[J]. 新疆农业科学, 2022, 59(11): 2772-2778.
[13]	张雪敏, 姚新奎, 孟军, 曾亚琦, 王建文, 叶尔哈拿提·卡得尔汗, 哈丽斯汗·巴哈依丁. 母源补喂竹叶提取物对伊犁马幼驹血液生化指标的影响[J]. 新疆农业科学, 2022, 59(11): 2779-2785.
[14]	石乐天, 陈勇臻, 郭腾达, 刘金铄, 张光辉, 陈鹏举. 豆腐果苷对脂多糖诱导的猪小肠上皮细胞损伤分析[J]. 新疆农业科学, 2022, 59(10): 2595-2600.
[15]	刘志刚, 任红松, 买买提·艾合买提, 胡西单·买买提, 努尔孜叶古丽·马合木提, 阿木提·库尔班, 王瑞华, 李海峰. 氨基酸硒叶面肥对吐鲁番秋季露地甜瓜叶片早衰生理特性的影响[J]. 新疆农业科学, 2021, 58(6): 1078-1085.