新疆农业科学 ›› 2022, Vol. 59 ›› Issue (9): 2267-2275.DOI: 10.6048/j.issn.1001-4330.2022.09.022
• 畜牧兽医·农业装备工程与机械化·农业经济 • 上一篇 下一篇
刘律1(), 李晓斌1, 马艳1, 杨昊1, 张文杰1, 鲁豪1, 卫鑫岚1, 高俊杰1, 欧阳文2, 杨开伦1()
收稿日期:
2021-11-15
出版日期:
2022-09-20
发布日期:
2023-01-16
通信作者:
杨开伦
作者简介:
刘律(1994-),女,山东滨州人,硕士研究生,研究方向为动物营养与饲料科学,(E-mail)2367474907@qq.com
基金资助:
LIU Lv1(), LI Xiaobin1, MA Yan1, YANG Hao1, ZHANG Wenjie1, LU Hao1, WEI Xinlan1, GAO Junjie1, OUYANG Wen2, YANG Kailun1()
Received:
2021-11-15
Online:
2022-09-20
Published:
2023-01-16
Correspondence author:
YANG Kailun
Supported by:
摘要:
【目的】 研究补喂胍基乙酸(GAA)对伊犁马血浆胍基乙酸、肌酸浓度的影响。【方法】 选取20匹年龄为2~3岁、体重[(373.2±30.53)kg]相近且经过严格训练的速度赛用伊犁马,随机分为4组,每组5匹(3♀+2♂),每日等强度训练。每匹马每天饲喂精料补充料4 kg,自由采食青干草,各组每天每匹马分别补喂0(CON组)、25(25 GAA组)、50(50 GAA组)和75 mg/kg BW(75 GAA组)的胍基乙酸。【结果】 (1)补喂胍基乙酸极显著提高了50 GAA组马匹第1~10 d以及75 GAA 组马匹7 d、10 d的饲喂后2 h血浆Cr/GAA(P<0.01),显著提高了50 GAA组马匹第7 d、10 d的饲喂后2 h血浆肌酐浓度(P<0.05)。(2)补喂胍基乙酸极显著提高了各试验组血浆Cr/GAA(P<0.01),极显著提高了50、75 GAA组马匹血浆肌酸浓度及24 h尿液肌酸代谢物排出量(P<0.01)。【结论】 补喂胍基乙酸提高了伊犁马血浆肌酸代谢物浓度,促进了伊犁马机体对胍基乙酸的快速吸收,以供机体利用,适宜添加水平为50 mg/kg BW。
中图分类号:
刘律, 李晓斌, 马艳, 杨昊, 张文杰, 鲁豪, 卫鑫岚, 高俊杰, 欧阳文, 杨开伦. 补喂胍基乙酸对运动训练伊犁马血浆胍基乙酸、肌酸浓度的影响[J]. 新疆农业科学, 2022, 59(9): 2267-2275.
LIU Lv, LI Xiaobin, MA Yan, YANG Hao, ZHANG Wenjie, LU Hao, WEI Xinlan, GAO Junjie, OUYANG Wen, YANG Kailun. CEffects of Supplemented with Guanidinoacetic Acid on the Plasma Guanidinoacetic Acid and Creatine Concentrations of Yili Horses During Exercise Training[J]. Xinjiang Agricultural Sciences, 2022, 59(9): 2267-2275.
项目 Items | 精料补充料 Concentrate supplement | 青干草 Green hay |
---|---|---|
干物质 DM | 92.06 | 94.11 |
有机物 OM | 91.11 | 93.55 |
粗脂肪 EE | 2.85 | 0.76 |
粗蛋白质 CP | 18.29 | 12.94 |
中性洗涤纤维 NDF | 25.82 | 59.33 |
酸性洗涤纤维 ADF | 7.92 | 29.73 |
钙 Ca | 0.77 | 0.93 |
磷 P | 1.20 | 0.12 |
表 1 试验精料补充料和青干草营养水平(干物质基础,%)
Table 1 Nutrient levels of concentrate supplementation and green hay (DM basis,%)
项目 Items | 精料补充料 Concentrate supplement | 青干草 Green hay |
---|---|---|
干物质 DM | 92.06 | 94.11 |
有机物 OM | 91.11 | 93.55 |
粗脂肪 EE | 2.85 | 0.76 |
粗蛋白质 CP | 18.29 | 12.94 |
中性洗涤纤维 NDF | 25.82 | 59.33 |
酸性洗涤纤维 ADF | 7.92 | 29.73 |
钙 Ca | 0.77 | 0.93 |
磷 P | 1.20 | 0.12 |
试验项目 (d) Testing days | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 | |
1 | 30.87±0.60B | 32.15±1.58B | 35.42±2.19A | 34.93±0.65A | <0.001 | <0.001 | 0.184 |
3 | 39.83±0.71bB | 37.21±0.64cBC | 46.56±0.78aA | 35.54±3.41cC | <0.001 | 0.346 | <0.001 |
5 | 43.81±1.72cC | 49.64±0.84bB | 56.65±1.82aA | 41.25±1.95dC | <0.001 | 0.840 | <0.001 |
7 | 37.26±0.81D | 47.60±0.38B | 55.22±0.78A | 41.58±1.45C | <0.001 | <0.001 | <0.001 |
10 | 35.03±0.29dC | 42.88±2.03bB | 52.84±2.76aA | 38.04±1.76cC | <0.001 | <0.001 | <0.001 |
表 2 补喂胍基乙酸下伊犁马饲喂后2 h血浆Cr/GAA变化
Table 2 Effects of supplemented with guanidineacetic acid on plasma Cr/GAA at 2 h after feeding in Yili horses(n=5)(%)
试验项目 (d) Testing days | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 | |
1 | 30.87±0.60B | 32.15±1.58B | 35.42±2.19A | 34.93±0.65A | <0.001 | <0.001 | 0.184 |
3 | 39.83±0.71bB | 37.21±0.64cBC | 46.56±0.78aA | 35.54±3.41cC | <0.001 | 0.346 | <0.001 |
5 | 43.81±1.72cC | 49.64±0.84bB | 56.65±1.82aA | 41.25±1.95dC | <0.001 | 0.840 | <0.001 |
7 | 37.26±0.81D | 47.60±0.38B | 55.22±0.78A | 41.58±1.45C | <0.001 | <0.001 | <0.001 |
10 | 35.03±0.29dC | 42.88±2.03bB | 52.84±2.76aA | 38.04±1.76cC | <0.001 | <0.001 | <0.001 |
试验项目 (d) Testing days | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 | |
1 | 89.21±7.13 | 93.92±7.14 | 94.42±6.58 | 90.51±8.61 | 0.628 | 0.739 | 0.905 |
3 | 84.99±5.58 | 84.48±3.44 | 89.87±7.64 | 82.44±2.21 | 0.176 | 0.828 | 0.153 |
5 | 80.96±4.27 | 85.22±5.92 | 86.38±4.26 | 83.61±3.95 | 0.319 | 0.299 | 0.375 |
7 | 84.43±7.62b | 89.37±4.89ab | 93.65±6.25a | 86.38±4.64ab | 0.021 | 0.537 | 0.261 |
10 | 88.42±8.49b | 96.09±3.96ab | 100.81±7.98a | 91.72±6.22ab | 0.040 | 0.329 | 0.212 |
表 3 补喂胍基乙酸下伊犁马饲喂后2 h血浆肌酐浓度变化
Table 3 Effects of supplemented with guanidineacetic acid on plasma creatinine concentration at 2 h after feeding in Yili horses(n=5)(μmol/L)
试验项目 (d) Testing days | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 | |
1 | 89.21±7.13 | 93.92±7.14 | 94.42±6.58 | 90.51±8.61 | 0.628 | 0.739 | 0.905 |
3 | 84.99±5.58 | 84.48±3.44 | 89.87±7.64 | 82.44±2.21 | 0.176 | 0.828 | 0.153 |
5 | 80.96±4.27 | 85.22±5.92 | 86.38±4.26 | 83.61±3.95 | 0.319 | 0.299 | 0.375 |
7 | 84.43±7.62b | 89.37±4.89ab | 93.65±6.25a | 86.38±4.64ab | 0.021 | 0.537 | 0.261 |
10 | 88.42±8.49b | 96.09±3.96ab | 100.81±7.98a | 91.72±6.22ab | 0.040 | 0.329 | 0.212 |
项目 | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
Items | CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 |
饲喂前 Before feeding | 342.95±13.39A | 325.33±15.63AB | 303.42±17.15B | 321.33±17.64AB | 0.011 | 0.002 | 0.984 |
饲喂后1 h 1 hour after feeding | 314.36±19.11aA | 315.31±17.41aA | 280.81±9.82bB | 306.93±13.76aAB | 0.009 | 0.003 | 0.068 |
饲喂后2 h 2 hours after feeding | 308.79±11.13bcB | 323.11±13.75bB | 299.53±18.95cB | 355.73±18.91aA | <0.001 | 0.882 | <0.001 |
饲喂后3 h 3 hours after feeding | 324.98±20.92a | 306.75±18.87ab | 291.31±13.99b | 299.17±13.43b | 0.039 | 0.006 | 0.508 |
饲喂后4 h 4 hours after feeding | 330.51±19.06aA | 314.48±18.43abA | 279.16±20.91cB | 299.79±12.24bcAB | 0.003 | <0.001 | 0.778 |
饲喂后6 h 6 hours after feeding | 311.02±15.03aA | 292.82±10.28bAB | 271.12±13.45cB | 283.96±12.76bcB | 0.001 | <0.001 | 0.651 |
饲喂后9 h 9 hours after feeding | 306.23±15.20aAB | 294.83±7.73abAB | 281.61±13.41bB | 313.80±17.79aA | 0.012 | 0.068 | 0.117 |
饲喂后12 h 12 hours after feeding | 298.62±14.55abAB | 307.75±6.91aA | 277.25±20.19cB | 284.88±13.51bcAB | 0.019 | 0.009 | 0.217 |
表 4 补喂胍基乙酸下伊犁马血浆胍基乙酸浓度变化
Table 4 Effects of supplemented with guanidineacetic acid on plasma guanidine acetic acid concentration in Yili horse(n=5)(μmol/L)
项目 | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
Items | CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 |
饲喂前 Before feeding | 342.95±13.39A | 325.33±15.63AB | 303.42±17.15B | 321.33±17.64AB | 0.011 | 0.002 | 0.984 |
饲喂后1 h 1 hour after feeding | 314.36±19.11aA | 315.31±17.41aA | 280.81±9.82bB | 306.93±13.76aAB | 0.009 | 0.003 | 0.068 |
饲喂后2 h 2 hours after feeding | 308.79±11.13bcB | 323.11±13.75bB | 299.53±18.95cB | 355.73±18.91aA | <0.001 | 0.882 | <0.001 |
饲喂后3 h 3 hours after feeding | 324.98±20.92a | 306.75±18.87ab | 291.31±13.99b | 299.17±13.43b | 0.039 | 0.006 | 0.508 |
饲喂后4 h 4 hours after feeding | 330.51±19.06aA | 314.48±18.43abA | 279.16±20.91cB | 299.79±12.24bcAB | 0.003 | <0.001 | 0.778 |
饲喂后6 h 6 hours after feeding | 311.02±15.03aA | 292.82±10.28bAB | 271.12±13.45cB | 283.96±12.76bcB | 0.001 | <0.001 | 0.651 |
饲喂后9 h 9 hours after feeding | 306.23±15.20aAB | 294.83±7.73abAB | 281.61±13.41bB | 313.80±17.79aA | 0.012 | 0.068 | 0.117 |
饲喂后12 h 12 hours after feeding | 298.62±14.55abAB | 307.75±6.91aA | 277.25±20.19cB | 284.88±13.51bcAB | 0.019 | 0.009 | 0.217 |
项目 | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
Items | CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 |
饲喂前 Before feeding | 100.87±8.12B | 110.94±8.87AB | 117.17±5.73A | 119.02±7.03A | 0.007 | 0.002 | 0.096 |
饲喂后1 h 1 hour after feeding | 93.48±5.54B | 98.18±7.11B | 116.02±7.35A | 112.58±7.33A | <0.001 | <0.001 | 0.838 |
饲喂后2 h 2 hours after feeding | 98.86±4.69cB | 114.01±7.61bB | 143.47±12.09aA | 138.52±7.83aA | <0.001 | <0.001 | 0.197 |
饲喂后3 h 3 hours after feeding | 93.48±7.88B | 101.25±7.35B | 126.37±5.54A | 123.07±7.66A | <0.001 | <0.001 | 0.103 |
饲喂后4 h 4 hours after feeding | 107.38±5.81 | 113.78±10.41 | 111.25±7.71 | 111.44±4.11 | 0.599 | 0.524 | 0.362 |
饲喂后6 h 6 hours after feeding | 110.47±7.29ab | 105.08±6.65b | 116.88±8.95a | 110.88±7.56ab | 0.0210 | 0.374 | 0.963 |
饲喂后9 h 9 hours after feeding | 91.78±6.07C | 108.22±6.26B | 121.42±4.85A | 115.54±7.75AB | <0.001 | <0.001 | 0.080 |
饲喂后12 h 12 hours after feeding | 105.48±6.70bB | 117.08±7.92aAB | 123.49±9.94aA | 105.71±6.35bB | 0.005 | 0.015 | 0.392 |
表 5 补喂胍基乙酸下伊犁马血浆肌酸浓度变化
Table 5 Effects of supplemented with guanidineacetic acid on plasma creatine concentration in Yili horse(n=5)(μmol/L)
项目 | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
Items | CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 |
饲喂前 Before feeding | 100.87±8.12B | 110.94±8.87AB | 117.17±5.73A | 119.02±7.03A | 0.007 | 0.002 | 0.096 |
饲喂后1 h 1 hour after feeding | 93.48±5.54B | 98.18±7.11B | 116.02±7.35A | 112.58±7.33A | <0.001 | <0.001 | 0.838 |
饲喂后2 h 2 hours after feeding | 98.86±4.69cB | 114.01±7.61bB | 143.47±12.09aA | 138.52±7.83aA | <0.001 | <0.001 | 0.197 |
饲喂后3 h 3 hours after feeding | 93.48±7.88B | 101.25±7.35B | 126.37±5.54A | 123.07±7.66A | <0.001 | <0.001 | 0.103 |
饲喂后4 h 4 hours after feeding | 107.38±5.81 | 113.78±10.41 | 111.25±7.71 | 111.44±4.11 | 0.599 | 0.524 | 0.362 |
饲喂后6 h 6 hours after feeding | 110.47±7.29ab | 105.08±6.65b | 116.88±8.95a | 110.88±7.56ab | 0.0210 | 0.374 | 0.963 |
饲喂后9 h 9 hours after feeding | 91.78±6.07C | 108.22±6.26B | 121.42±4.85A | 115.54±7.75AB | <0.001 | <0.001 | 0.080 |
饲喂后12 h 12 hours after feeding | 105.48±6.70bB | 117.08±7.92aAB | 123.49±9.94aA | 105.71±6.35bB | 0.005 | 0.015 | 0.392 |
项目 | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
Items | CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 |
饲喂前 Before feeding | 29.37±1.24C | 34.07±1.40B | 38.63±0.87A | 37.05±1.35A | <0.001 | <0.001 | <0.001 |
饲喂后1 h 1 hour after feeding | 29.74±0.82C | 31.12±0.79C | 41.28±1.23A | 36.68±1.62B | <0.001 | <0.001 | <0.001 |
饲喂后2 h 2 hours after feeding | 32.01±0.75D | 35.26±1.20C | 47.85±1.66A | 38.93±0.47B | <0.001 | <0.001 | <0.001 |
饲喂后3 h 3 hours after feeding | 28.75±1.29D | 32.99±0.53C | 43.39±0.57A | 41.11±0.78B | <0.001 | <0.001 | <0.001 |
饲喂后4 h 4 hours after feeding | 32.49±0.35C | 36.12±1.25B | 39.86±0.59A | 37.18±0.70B | <0.001 | <0.001 | <0.001 |
饲喂后6 h 6 hours after feeding | 35.49±0.78C | 35.86±1.29C | 42.81±1.14A | 39.02±1.31B | <0.001 | <0.001 | 0.001 |
饲喂后9 h 9 hours after feeding | 29.95±0.62C | 36.68±1.18B | 43.13±0.71A | 36.81±1.14B | <0.001 | <0.001 | <0.001 |
饲喂后12 h 12 hours after feeding | 35.31±0.91cC | 38.01±1.83bB | 44.52±0.56aA | 37.09±1.12bBC | <0.001 | <0.001 | <0.001 |
表 6 补喂胍基乙酸下伊犁马血浆Cr/GAA变化
Table 6 Effect of guanidine acetic acid supplementation on plasma Cr/GAA in Yili horse(n=5)
项目 | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
Items | CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 |
饲喂前 Before feeding | 29.37±1.24C | 34.07±1.40B | 38.63±0.87A | 37.05±1.35A | <0.001 | <0.001 | <0.001 |
饲喂后1 h 1 hour after feeding | 29.74±0.82C | 31.12±0.79C | 41.28±1.23A | 36.68±1.62B | <0.001 | <0.001 | <0.001 |
饲喂后2 h 2 hours after feeding | 32.01±0.75D | 35.26±1.20C | 47.85±1.66A | 38.93±0.47B | <0.001 | <0.001 | <0.001 |
饲喂后3 h 3 hours after feeding | 28.75±1.29D | 32.99±0.53C | 43.39±0.57A | 41.11±0.78B | <0.001 | <0.001 | <0.001 |
饲喂后4 h 4 hours after feeding | 32.49±0.35C | 36.12±1.25B | 39.86±0.59A | 37.18±0.70B | <0.001 | <0.001 | <0.001 |
饲喂后6 h 6 hours after feeding | 35.49±0.78C | 35.86±1.29C | 42.81±1.14A | 39.02±1.31B | <0.001 | <0.001 | 0.001 |
饲喂后9 h 9 hours after feeding | 29.95±0.62C | 36.68±1.18B | 43.13±0.71A | 36.81±1.14B | <0.001 | <0.001 | <0.001 |
饲喂后12 h 12 hours after feeding | 35.31±0.91cC | 38.01±1.83bB | 44.52±0.56aA | 37.09±1.12bBC | <0.001 | <0.001 | <0.001 |
项目 | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
Items | CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 |
饲喂前 Before feeding | 76.12±3.81 | 75.45±5.62 | 79.91±5.32 | 81.02±4.09 | 0.215 | 0.062 | 0.683 |
饲喂后1 h 1 hour after feeding | 74.85±5.32 | 71.81±5.10 | 79.03±6.46 | 76.66±2.84 | 0.192 | 0.233 | 0.884 |
饲喂后2 h 2 hours after feeding | 69.85±6.62 | 67.22±5.63 | 73.98±4.57 | 69.61±4.56 | 0.297 | 0.586 | 0.725 |
饲喂后3 h 3 hours after feeding | 67.83±4.30 | 70.71±5.67 | 72.49±4.50 | 72.97±1.89 | 0.265 | 0.064 | 0.544 |
饲喂后4 h 4 hours after feeding | 72.69±6.25 | 75.09±6.17 | 77.11±5.22 | 74.75±4.53 | 0.673 | 0.474 | 0.356 |
饲喂后6 h 6 hours after feeding | 74.86±4.41 | 77.57±5.53 | 78.97±5.48 | 79.43±4.81 | 0.503 | 0.157 | 0.627 |
饲喂后9 h 9 hours after feeding | 74.07±7.58 | 78.67±6.11 | 80.04±4.25 | 77.89±5.55 | 0.458 | 0.301 | 0.226 |
饲喂后12 h 12 hours after feeding | 74.17±6.99 | 77.23±3.01 | 79.85±5.06 | 79.24±4.77 | 0.331 | 0.103 | 0.438 |
表 7 补喂胍基乙酸下伊犁马血浆肌酐浓度变化
Table 7 Effects of supplemented with guanidineacetic acid on plasma creatinine concentration in Yili horse(n=5)(μmol/L)
项目 | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
Items | CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 |
饲喂前 Before feeding | 76.12±3.81 | 75.45±5.62 | 79.91±5.32 | 81.02±4.09 | 0.215 | 0.062 | 0.683 |
饲喂后1 h 1 hour after feeding | 74.85±5.32 | 71.81±5.10 | 79.03±6.46 | 76.66±2.84 | 0.192 | 0.233 | 0.884 |
饲喂后2 h 2 hours after feeding | 69.85±6.62 | 67.22±5.63 | 73.98±4.57 | 69.61±4.56 | 0.297 | 0.586 | 0.725 |
饲喂后3 h 3 hours after feeding | 67.83±4.30 | 70.71±5.67 | 72.49±4.50 | 72.97±1.89 | 0.265 | 0.064 | 0.544 |
饲喂后4 h 4 hours after feeding | 72.69±6.25 | 75.09±6.17 | 77.11±5.22 | 74.75±4.53 | 0.673 | 0.474 | 0.356 |
饲喂后6 h 6 hours after feeding | 74.86±4.41 | 77.57±5.53 | 78.97±5.48 | 79.43±4.81 | 0.503 | 0.157 | 0.627 |
饲喂后9 h 9 hours after feeding | 74.07±7.58 | 78.67±6.11 | 80.04±4.25 | 77.89±5.55 | 0.458 | 0.301 | 0.226 |
饲喂后12 h 12 hours after feeding | 74.17±6.99 | 77.23±3.01 | 79.85±5.06 | 79.24±4.77 | 0.331 | 0.103 | 0.438 |
项目 | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
Items | CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 |
胍基乙酸 Guanidineacetic acid(mg) | 98.63±3.12C | 111.18±6.95C | 143.83±5.88B | 167.61±13.51A | <0.001 | <0.001 | 0.295 |
肌酸 Creatine(mg) | 52.78±3.23C | 74.01±2.72B | 89.72±7.25A | 71.17±6.71B | <0.001 | <0.001 | <0.001 |
肌酐 Creatinine(g) | 1.97±0.14C | 2.62±0.16B | 3.25±0.22A | 2.59±0.26B | <0.001 | <0.001 | <0.001 |
表 8 补喂胍基乙酸下伊犁马24 h尿液肌酸代谢物排出量变化
Table 8 Effect of guanidine acetic acid supplementation on 24 h urinary creatine metabolite excretion in Yili horse(n=5)
项目 | 组别 Groups | P值 P-value | |||||
---|---|---|---|---|---|---|---|
Items | CON | 25 GAA | 50 GAA | 75 GAA | 总体 | 线性 | 二次 |
胍基乙酸 Guanidineacetic acid(mg) | 98.63±3.12C | 111.18±6.95C | 143.83±5.88B | 167.61±13.51A | <0.001 | <0.001 | 0.295 |
肌酸 Creatine(mg) | 52.78±3.23C | 74.01±2.72B | 89.72±7.25A | 71.17±6.71B | <0.001 | <0.001 | <0.001 |
肌酐 Creatinine(g) | 1.97±0.14C | 2.62±0.16B | 3.25±0.22A | 2.59±0.26B | <0.001 | <0.001 | <0.001 |
[1] |
Reardon T F, Ruell P A, Fiatarone S M A, et al. Creatine supplementation does not enhance submaximal aerobic training adaptations in healthy young men and women[J]. European Journal of Applied Physiology, 2006, 98(3):234-241.
PMID |
[2] |
Maccormick V M, Hill L M, Macneil L, et al. Elevation of creatine in red blood cells in vegetarians and nonvegetarians after creatine supplementation[J]. Canadian Journal of Applied Physiology, 2004, 29(6):704-713.
PMID |
[3] |
SEWELL D A, HARRIS R C. Effects of creatine supplementation in the thoroughbred horse[J]. Equine Veterinary Journal, 1995, 27(18):239-242.
DOI URL |
[4] | 李晓斌, 马军, 聂彪彪, 等. 补喂肌酸对速步马运动性能、糖代谢及抗氧化能力的影响[J]. 动物营养学报, 2016, 28(5):1506-1514. |
LI Xiaobin, MA Jun, NIE Biaobiao, et al. Effects of creatine supplementation on exercise performance, glucose metabolism and antioxidation of speedhorses[J]. Chinese Journal of Animal Nutrition, 2016, 28(5):1506-1514. (in Chinese) | |
[5] | 张德福, 田耀耀, 马佳, 等. 胍基乙酸对AA肉仔鸡生长性能和经济效益的影响[J]. 饲料研究, 2016,(17):32-35. |
ZHANG Defu, TIAN Yaoyao, MA Jia, et al. Effects of guanidine acetic acid on growth performance and economic benefit of AA broilers[J]. Feed Research, 2016,(17):32-35. | |
[6] | EDISON E E, BROSNAN M E, MEYER C, et al. Creatine synthesis: production of guanidinoacetate by the rat and human kidney in vivo[J]. Am J Physiol Renal Physiol, 2007, 293(6):1799-1804. |
[7] | WEBER C J. Studies on the metabolism of guanidoacetic acid[J]. Hope-Seylers Z Physiol Chein, 1936,(114):cvii. |
[8] |
OSTOJIC S M. Guanidinoacetic acid as a performance-enhancing agent[J]. Amino Acids, 2016, 48(8):1867-1875.
DOI PMID |
[9] | OSTOJIC S M, NIESS B, STOJANOVIC M D, et al. Serum creatine, creatinine and total homocysteine concentration-time profiles after a single oral dose of guanidinoacetic acid in humans[J]. Journal of Functional Foods, 2014,(6):598-605. |
[10] |
LU Y, ZOU T, WANG Z, et al. Dietary guanidinoacetic acid improves the growth performance and skeletal muscle development of finishing pigs through changing myogenic gene expression and myofibre characteristics[J]. Journal of Animal Physiology and Animal Nutrition, 2020, 104(6):1875-1883.
DOI URL |
[11] | Setoue M, Ohuchi S, Morita T, et al. Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats[J]. Bioscience, Biotechnology, and Biochemistry, 2008, 72(7):1696-1703. |
[12] |
Wada T, Wada T, Shimbo H, et al. A simple screening method using ion chromatography for the diagnosis of cerebral creatine deficiency syndromes[J]. Amino Acids, 2012, 43(2):993-997.
DOI PMID |
[13] | WYSS M, KADDURAH-DAOUK R. Creatine and creatinine metabolism[J]. Physiological Reviews, 2000, 3(80):1107-1213. |
[14] | 王连生, 张圆圆, 单安山. 胍基乙酸的体内代谢及在动物生产中的应用[J]. 中国畜牧兽医, 2010, 37(6):13-16. |
Wang Liansheng, Zhang Yuanyuan, Shan Anshan. Metabolism of Guanidine Acetic Acid and Application in Animal Production[J]. Chinese Animal Husbandry and Veterinary Medicine, 2010, 37(6):13-16. | |
[15] | 王誉杰, 张进威, 王讯, 等. 胍基乙酸及代谢产物肌酸的研究进展[J]. 畜牧兽医学报, 2018, 49(8):1577-1584. |
WANG Yujie, ZHANG Jinwei, WANG Xun, et al. Advances in studies on guanidine acetic acid and its metabolite creatine[J]. Chinese Journal of Animal Husbandry and Veterinary Medicine, 2018, 49(8):1577-1584. | |
[16] | 晁雅琳, 刘博, 寇启芳, 等. 胍基乙酸对舍饲滩羊生长性能、屠宰性能、脂肪沉积及肌肉营养成分的影响[J]. 动物营养学报, 2019, 31(1):388-394. |
YAO Yalin, LIU Bo, KOU Qifang, et al. Effects of guanidine acetic acid on growth performance, slaughtering performance, fat deposition and muscle nutritional composition of house-fed tan sheep[J]. Chinese Journal of Animal Nutrition, 2019, 31(1):388-394. | |
[17] |
Kodambashi Emami N, Golian A, Rhoads D D, et al. Interactive effects of temperature and dietary supplementation of arginine or guanidinoacetic acid on nutritional and physiological responses in male broiler chickens[J]. British Poultry Science, 2017, 58(1):87-94.
DOI PMID |
[18] |
Majdeddin M, Braun U, Lemme A, et al. Guanidinoacetic acid supplementation improves feed conversion in broilers subjected to heat stress associated with muscle creatine loading and arginine sparing[J]. Poult Sci, 2020, 99(9):4442-4453.
DOI URL |
[19] |
HE D T, GAI X R, YANG L B, et al. Effects of guanidinoacetic acid on growth performance, creatine and energy metabolism, and carcass characteristics in growing-finishing pigs[J]. Journal of Animal Science, 2018, 96(8):3264-3273.
DOI PMID |
[20] | Persky A M, Brazeau G A, Gunther H. Pharmacokinetics of the dietary supplement creatine[J]. Clinical Pharmacokinetics, 2003, 6(42):557-574. |
[21] |
Soboll S, Conrad A, Eistert A, et al. Uptake of creatine phosphate into heart mitochondria: a leak in the creatine shuttle[J]. Biochim Biophys Acta, 1997, 1320(1):27-33.
PMID |
[22] |
LI S Y, WANG C, WU Z Z, et al. Effects of guanidinoacetic acid supplementation on growth performance, nutrient digestion, rumen fermentation and blood metabolites in angus bulls[J]. Animal, 2020, 14(12):2535-2542.
DOI URL |
[23] | TachikawA M, Ikeda S, FujinawA J, et al. γ-aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats[J]. PLoS One, 2012, 7(2):1-9. |
[1] | 朱静, 张志东, 唐琦勇, 顾美英. 基于Biolog FF技术解析辐射对产黑色素短梗霉代谢活性的影响[J]. 新疆农业科学, 2023, 60(8): 2046-2054. |
[2] | 刘阳, 白羽嘉, 张郑啸, 楚晨俐, 王甜甜, 冯作山. 甜瓜抗链格孢侵染病程相关蛋白及苯丙烷代谢酶的变化[J]. 新疆农业科学, 2023, 60(7): 1780-1789. |
[3] | 常雪花, 闫波雯, 翟荣臻, 张政, 吴斌, 魏佳. 二氧化硫对木纳格葡萄采后糖含量及糖代谢途径的影响[J]. 新疆农业科学, 2023, 60(5): 1216-1225. |
[4] | 张仕琦, 李晓斌, 张文杰, 韩明, 王世昌, 郑文祥, 欧阳文, 祁居中, 杨开伦. 基于LC/MS的伊犁马3 600 m速度赛赛前、赛后血浆代谢组学差异变化[J]. 新疆农业科学, 2023, 60(2): 501-510. |
[5] | 王威, 徐乐, 樊艳星, 王帆, 马艳明, 唐中华. 鹰嘴豆种子代谢产物的GC-MS分析[J]. 新疆农业科学, 2023, 60(12): 2962-2972. |
[6] | 王辉, 董永梅, 郭伟锋, 曹新川, 郭金成, 谢宗铭, 何良荣. 高温胁迫下陆地棉转录组差异性分析[J]. 新疆农业科学, 2023, 60(11): 2618-2626. |
[7] | 杨世英, 马玉娥, 贾斌鑫, 华震宇, 沈琦, 刘峰娟, 王成. 油菜素内酯对甜瓜农药残留的降解作用分析[J]. 新疆农业科学, 2023, 60(10): 2541-2550. |
[8] | 王明, 刘子豪, 程平, 杨璐, 张志刚, 李宏. 不同贮藏方式对油桃呼吸代谢和质构指标的影响[J]. 新疆农业科学, 2022, 59(7): 1650-1658. |
[9] | 阿塔吾拉·铁木尔, 阿布来克·尼牙孜, 田全明, 张健, 徐斌, 吴斌. “吊挂式”窖藏对冬季白菜贮藏品质及活性氧代谢的保鲜作用分析[J]. 新疆农业科学, 2022, 59(5): 1292-1300. |
[10] | 布妈热娅木·艾山, 潘俨, 孙席, 徐斌, 孟新涛, 张婷. 采收成熟度对核桃青皮褐变及相关代谢酶的影响[J]. 新疆农业科学, 2022, 59(12): 3066-3074. |
[11] | 郑新霞, 张文举, 刘艳丰, 牛玉杰, 王海亮, 张莉. 不同饲喂水平对20~35 kg多胎萨福克羊母羊消化代谢及血清指标的影响[J]. 新疆农业科学, 2022, 59(12): 3104-3111. |
[12] | 王洁, 孟军, 曾亚琦, 王建文, 吐尔逊江·吾木尔艾力, 王川坤, 袁鑫鑫, 王彤亮, 姚新奎. 伊犁马PFKM基因表达及酶活性分析[J]. 新疆农业科学, 2022, 59(11): 2758-2764. |
[13] | 王建文, 丁玉泽, 李璐伶, 姚新奎, 曾亚琦, 闫睛, 任万路, 王川坤, 孟军. 伊犁马LPL基因多态性及其与肉质性状关联性分析[J]. 新疆农业科学, 2022, 59(11): 2765-2771. |
[14] | 吴睿宸, 姚新奎, 孟军, 曾亚琦, 王川坤, 阿拉法特·艾合买提, 努尔塔依·库尔班塔依. 补饲不同剂量竹叶提取物对泌乳期伊犁马血液生化指标的影响[J]. 新疆农业科学, 2022, 59(11): 2772-2778. |
[15] | 张雪敏, 姚新奎, 孟军, 曾亚琦, 王建文, 叶尔哈拿提·卡得尔汗, 哈丽斯汗·巴哈依丁. 母源补喂竹叶提取物对伊犁马幼驹血液生化指标的影响[J]. 新疆农业科学, 2022, 59(11): 2779-2785. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||