复方金栀制剂对脂多糖致热鸡解热作用

doi:10.6048/j.issn.1001-4330.2021.01.021

新疆农业科学 ›› 2021, Vol. 58 ›› Issue (1): 176-181.DOI: 10.6048/j.issn.1001-4330.2021.01.021

复方金栀制剂对脂多糖致热鸡解热作用

李璐璐¹, 姜苏², 范子洋², 赵红琼¹, 郝智慧^2,3

1.新疆农业大学动物医学学院,乌鲁木齐 830052;
2.青岛农业大学化学与药学院,山东青岛 266109;
3.中国农业大学动物医学院,北京 100193

收稿日期:2019-03-04 出版日期:2021-01-20 发布日期:2021-01-20
通信作者: 郝智慧(1980 - ),女,内蒙古赤峰人,教授,研究方向为兽医药理学及动物新药,(E-mail)abplab @ 126. com
作者简介:李璐璐(1993 - ),女,四川渠县人,硕士研究生,研究方向为生物活性物质结构和功能,(E-mail)lilulu_1227 @ sina. cn
基金资助:
新疆维吾尔自治区科技支疆项目(2017E0242)

Studies on Antipyretic Effect of Compound Jinzhi Preparation on Lipopolysaccharide-induced Pyrexia in Chickens

LI Lulu¹, JIANG Su², FAN Ziyang², ZHAO Hongqiong¹, HAO Zhihui³

1. College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi 830052, China;
2. College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao Shandong 266109, China;
3. College of Veterinary Medicine, China Agricultural University, Beijing 100193, China

Received:2019-03-04 Online:2021-01-20 Published:2021-01-20
Correspondence author: HAO Zhihui (1980 - ), female, native place: Chifeng, Inner Mongolia Autonomous Region, professor, research field: The veterinary pharmacology and new veterinary drugs research, (E - mail) abplab @ 126. com
Supported by:
The Project of S & T Supporting Xinjiang of Xinjiang Uygur Autonomous Region (2017E0242)

摘要/Abstract

摘要： 【目的】 复方金栀制剂由具有清热解毒功效的青蒿、金银花和栀子组方,研究其对禽类炎症引起发热的解热效果。为禽类中药解热药的筛选提供药效学依据。【方法】 用腹腔注射脂多糖的方法制备鸡只炎症发热模型,肌肉注射260 mg/100g体重复方金栀制剂,注射前后每隔1 h监测鸡只肛门体温。【结果】 脂多糖注射后2 h发热模型组鸡只体温极显著高于空白对照组(P < 0.01),且持续到注射后7 h。发热鸡只复方金栀制剂给药后1 h体温显著低于发热模型组(P < 0.05),之后体温同发热模型组比较差异不显著(P > 0.05)。不同给药处理与时间交互对鸡只体温影响均极显著(P < 0.01)。【结论】 复方金栀制剂对脂多糖引起的鸡只发热具有解热作用,但作用时间较短。

关键词: 复方金栀制剂; 脂多糖; 发热模型; 解热作用; 鸡

Abstract: 【Objective】 The compound Jinzhi preparation (CJZ) is composed of Artemisiae annuae herba, Lonicera japonica flos, and Gardenia jasminoides ellis, which were found to have antipyretic and detoxifying functions. The present study aims to investigate the antipyretic effect of CJZ induced by inflammation in avian. 【Methods】 Building pyretic model of chicken inflammation by intraperitoneal injection of lipopolysaccharide (LPS) , followed by intramuscular injection of CJZ in a dose of 260 mg/100g body weight. The anal temperature of chickens was monitored per hour before and after injection.【Results】 The present results showed that anal temperature in the pyretic model group was significantly higher than that of the blank control group at 2 h after LPS injection (P < 0.01), and continued to 7 h after the injection. Anal temperature in the Jinzhi group was significantly lower than that in the pyretic model group at 1 hour after administration of JCZ (P <0.05), however, it was not significantly different from that in the pyretic model group from 2 h to 6 h after administration (P > 0.05). Two-way ANOVA results showed that the effects of different drug administration and time interactions on chicken’s temperature were significantly different (P < 0.01). 【Conclusion】 The above results demonstrated that CJZ has antipyretic effect on LPS-induced pyrexia in chickens, but the action time is short. These results can be used as reference for the pharmacodynamic studies on antipyretic drugs in avian.

Key words: compound Jinzhi preparation; lipopolysaccharide; pyretic model; antipyretic effect; chicken

中图分类号:

S853.2

李璐璐, 姜苏, 范子洋, 赵红琼, 郝智慧. 复方金栀制剂对脂多糖致热鸡解热作用[J]. 新疆农业科学, 2021, 58(1): 176-181.

LI Lulu, JIANG Su, FAN Ziyang, ZHAO Hongqiong, HAO Zhihui. Studies on Antipyretic Effect of Compound Jinzhi Preparation on Lipopolysaccharide-induced Pyrexia in Chickens[J]. Xinjiang Agricultural Sciences, 2021, 58(1): 176-181.

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复方金栀制剂对脂多糖致热鸡解热作用

Studies on Antipyretic Effect of Compound Jinzhi Preparation on Lipopolysaccharide-induced Pyrexia in Chickens

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