新疆伊犁地区不同动物源大肠杆菌耐药性调查

doi:10.6048/j.issn.1001-4330.2018.08.022

摘要/Abstract

摘要： 【目的】研究新疆伊犁地区不同动物源大肠杆菌对临床常用抗菌药物的耐药情况。为临床合理用药和防止大肠杆菌产生耐药性提供科学依据。【方法】采用琼脂稀释法对伊犁地区不同动物源粪样中分离出的723株大肠杆菌(猪源89株、牛源164株、鸡源270株和羊源200株)进行临床常用10种抗菌药物的耐药性检测。【结果】(1)牛源大肠杆菌主要对安普霉素(26.8%)耐药;多药耐药以0耐(62.0%)为主。(2)羊源大肠杆菌主要对阿莫西林/克拉维酸(77.5%)、氨苄西林(69.5%)、恩诺沙星(46.0%)、诺氟沙星(45.0%)和安普霉素(43.5%)耐药;多药耐药以4耐(16.0%)和6耐(16.0%)为主。(3)猪源大肠杆菌主要对氨苄西林(66.0%)、阿莫西林/克拉维酸(64.0%)、氟苯尼考(64.0%)、恩诺沙星(53.0%)、诺氟沙星(49.0%)、环丙沙星(36.0%)和庆大霉素(31.0%)耐药;多药耐药以2耐(12.0%)、5耐(13.0%)和7耐(12.0%)为主。(4)鸡源大肠杆菌主要对氨苄西林(74.4%)、阿莫西林/克拉维酸(73.0%)、氟苯尼考(71.1%)、恩诺沙星(65.9%)、诺氟沙星(61.1%)耐药;多药耐药以7耐(17.7%)和8耐(14.4%)为主。【结论】不同动物源大肠杆菌耐药程度由高到依次为鸡源菌>羊源菌>猪源菌>牛源菌,加强伊犁地区大肠杆菌的耐药性检测。

关键词: 动物; 大肠杆菌; 耐药性; 多药耐药

Abstract: 【Objective】 In order to understand the resistance to clinical antibacterial drugs of Escherichia coli derived from different animal origins in Yili, Xinjiang.【Method】 Agar dilution method was used to detect the resistance of 10 kinds of antimicrobial agents to 723 strains of Escherichia coli (89 strains were isolated from pigs, 164 strains were isolated from cattle, 270 strains were isolated from chicken and 200 strains were isolated from sheep) isolated from feces from different animal sources in Yili area.【Result】 The results showed that: ⑴ the resistance rates of cattle source Escherichia coli was mainly resistant to amphotericin (26.8%), and multidrug resistance was mainly resistant to 0 resistant (62%). ⑵ the resistance rates of sheep source Escherichia coli was mainly resistant to amoxicillin/clavulanic acid (77.5%), ampicillin (69.5%), enrofloxacin (46%), norfloxacin (45%) and amphotericin (43.5%), and multidrug resistance was concentrated in 4 resistant (16%) and 6 resistant (16%). ⑶ the resistance rates of pigs source Escherichia coli was mainly resistant to ampicillin (66%), amoxicillin/clavulanic acid (64%), florfenicol (64%), enrofloxacin (53%), norfloxacin (49%), ciprofloxacin (36%) and gentamicin (31%). The multidrug resistance was concentrated in 2 resistant (12%), 5 resistant (13%) and 7 resistant (12%). ⑷ the resistance rates of chicken source Escherichia coli was mainly resistant to ampicillin (74.4%), amoxicillin/clavulanic acid (73%), florfenicol (71.1%), enrofloxacin (65.9%), and norfloxacin (61.1%), and multidrug resistance was mainly based on 7 resistant (17.7%) and 8 resistant (14.4%).【Conclusion】 The order of drug resistance of Escherichia coli from different animal sources is: chicken source > sheep source > pig source > cattle source. It is necessary to strengthen the detection of drug resistance of Escherichia coli in Yili, so as to provide scientific basis for rational drug use and prevention of drug resistance of Escherichia coli.

Key words: animals; Escherichia coli; drug resistance; multidrug resistance

中图分类号:

S859.79

陈月月,王凯,王舒丰,姚晓慧,轩慧勇,马木尔,夏利宁. 新疆伊犁地区不同动物源大肠杆菌耐药性调查[J]. 新疆农业科学, 2018, 55(8): 1560-1568.

CHEN Yue-yue, WANG Kai, WANG Shu-feng, YAO Xiao-hui, XUAN Hui-yong, Mamuer Akemuhan, XIA Li-ning. Investigation into Drug Resistance of Escherichia coli from Different Animal Sources in Yili, Xinjiang[J]. Xinjiang Agricultural Sciences, 2018, 55(8): 1560-1568.

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