Abstract: 【Objective】 To study the effects of foliar application of different concentrations of amino acid selenium fertilizer on the physiology of early senescence of dew melon in autumn in Turpan, Xinjiang, and to select the best application concentration and frequency of amino acid selenium fertilizer in the technology of delaying and regulating early senescence. 【Methods】 Under the condition of autumn open field cultivation in Turpan, the main cultivar of melon Xizhoumi 17 was used as the test material, and different concentrations of amino acid selenium fertilizer were sprayed on the leaves from the beginning of flowering. The changes of chlorophyll, soluble protein content, malondialdehyde and antioxidant enzyme activity of different concentrations of amino acid selenium fertilizer on the leaves of melon were analyzed compared with that of clear water. And, the relationship with leaf premature senescence was studied as well. 【Results】 Compared with the control treatment with clear water, spraying amino acid selenium fertilizer of 2,000-2,500 times every 7 days for 6-7 times can effectively delayed the decline rate of relative chlorophyll content and soluble protein content in leaves during senescence, reduce the increase of MDA, and significantly improve the activity of antioxidant enzymes. 【Conclusion】 It is an ideal control measure to delay the senescence of muskmelon leaves by spraying amino acid selenium 2,000-2,500 times.