Abstract: Objective In this paper,the melanin produced by the batch fermentation of a radiation-resistant Aureobasidium pullulans MF1 and fermentation kinetics is studied.Method Cell growth,melanin production and glucose consumption throughout the melanin fermentation were investigated.The kinetic model was built to describe the cell growth,melanin production and glucose consumption based on Logistic equation and Luedeking-Piret equation.And the predictive values of models were compared with the experimental data.Result Results showed that kinetic properties in the production process of melanin by batch fermentation.The calculated result of model fit well with the experimental data.And calculated maximum melanin production of cell was 1.523 × 10-4 g/gglucose · gdry cell celt · h.Conclusion The kinetic model laid foundation for the pilot scale,large-scale production of water-soluble natural melanin in the future.