Abstract: 【Objective】 The aim of this study is to optimize the better extraction process of β-carotene from the skin residue of Xinjiang Lycium barbarum in order to promote the comprehensive utilization of Xinjiang Lycium barbarum resources.Provides theoretical basis and technical support for the high-value utilization of Lycium barbarum dregs. 【Methods】 Anhydrous ethanol was used as the extraction solvent, and the effects of material-liquid ratio, temperature, time, and the number of extraction times on the extraction amount of β-carotene from the skin dregs of Lycium barbarum were investigated. The extraction process was optimized by Random Centroid Optimization (RCO), and then the better extraction conditions were determined. In addition, the antioxidant capacity of β-carotene against DPPH radicals and ABTS radicals was also determined. 【Results】 The optimized parameters of the best extraction process were: material-liquid ratio 1∶16 g/mL, temperature 48℃, time 41 min, and number of extractions twice. Under these conditions, the extracted amount of β-carotene reached 0.53 mg/g. β-carotene showed good antioxidant ability, and the scavenging rates of DPPH and ABTS radicals were 60.89% and 66.11% at a mass concentration of 1.0 mg/mL, respectively. 【Conclusion】