Abstract: 【Objective】 Carried out the simulation and optimization of the air-source heat pump-buried pipe system in solar greenhouses to explore the optimal working parameters of the system. They also provide case references for the research and engineering applications related to greenhouse winter heating in the Gobi and desert regions of Xinjiang. 【Methods】 The research object in this study is the air source heat pump heat collection combined with underground pipe thermal storage (ASHP-UP) system. The transient simulation model is built using TRNSYS software, and the Box-Behnken experimental design and response surface analysis method is used to study and optimize the system operation parameters. 【Results】 Under the optimal working condition, the heat storage capacity of the system is 501.90 kWh, the energy consumption is 77.18 kWh, and the soil is warmed up by 2.26 ℃. The average daily heat storage power of the system is 37.5 kJ/s, the average daily heat storage COP is 4.33, and the exothermic COP is 4.81. Compared with the traditional heating methods of coal, gas, and electricity, the energy consumption is reduced by 84.7%, 81.3%, and 79.1%, respectively, and the GHG emission is reduced by 8.24, 6.52, and 5.67 t, respectively. The optimal working conditions of the system in winterized production are: rated heat production capacity of the heat pump is 30.0 kW, heat storage time is 12.0 h, and circulating water flow rate is 5.55 m³/h. 【Conclusion】 Measurements have verified that the system has good heat storage and release effects, meets the crop overwintering production needs, and its energy-saving and environmental performance meets the national energy-saving and emission reduction requirements.