Abstract: 【Objective】 Tomato root rot caused by Fusarium solani widely occurs in northwestern China, which has resulted serious negative effects, in view of this, this project aims to provide support for the prevention and control of that by screening excellent resistant varieties and fungicides. 【Methods】 Fusarium solani, the dominant pathogen of tomato root rot in northwestern China, was chosen as the target, pot-culture method was used to identify the resistance of 33 tomato varieties, the incidence rate and disease index of them were counted to conduct their resistance grades. The virulence effects of 7 fungicides were measured by mycelium growth rate inhibition method, and their field control effects were determined by root-filling method. 【Results】 Yuanminghongyunv and Taiwanfenyunv were resistant varieties, their incidence were the same with 27.77%, and their disease indexes were 9.70 and 13.90, respectively. Besides, Moguiyingtao and Fenguan 1 Jingpinhongmeimu were middle resistant varieties(MR), while the others were with poorer resistance. 7 kinds of fungicides had different inhibitory effects on Fusarium solani, and among them, 12.5% diniconazole WP had the strongest toxicity against Fusarium solani, with inhibition rate reached 79.80%, EC₅₀ was 24.86 μg/mL, and the highest field control effect reached 47.52%. The toxicity of 30% thiazenol copper pentazolol SC and 15% triazolone WP were lower, with EC₅₀ 30.93 μg/mL and 38.46 μg/mL, field control effects were 45.89% and 43.95%, respectively. 【Conclusion】 Yuanminghongyunv and Taiwanfenyunv were resistant varieties, and diniconazole has excellent control effect for tomato Fusarium solani root rot.