Abstract: 【Objective】 Screened and selected fungicide-selenium co-formulations to reduce fungicide dosage while enhancing their control efficacy against sunflower sclerotinia caused by Sclerotinia sclerotiorum,thereby providing a novel theoretical foundation for managing this disease in Xinjlang. 【Methods】 The effects of fluroxonil and benzalpyrimidin on mycelia growth, mycelia morphology, oxalic acid secretion and sclerotium production of S. sclerotiorum were measured after being combined with selenium separately, and their control efficacy on sunflower sclerotinia was verified by pot experiment. 【Results】 The combination of 0.5 mg/L fluroxonil and 1 mg/L benzalpyrimidin with 30 mg/L selenium significantly inhibited the mycelium growth and the generation of sclerotium, and the mycelium morphology changed. The secretion of sclerotinic acid decreased significantly after the combination of fluroxonil and selenium. In addition, the combination of two fungicides and selenium could improve the prevention and control effect of Sclerotinia stem rot to a certain extent. 【Conclusion】 Compared with a single dose, the combination of 0.5mg/L fludioxonil, 1mg/L benzyl azoxystrobin and 30mg/L selenium effectively hinder the normal growth and development of S. sclerotiorum, and enhance the protective effect on sunflower.