Abstract: 【Objective】 To discover candidate genes related to salt tolerance in potatoes and provide theoretical basis for the identification and evaluation of salt tolerance in potatoes and the exploration of salt tolerance genes. 【Methods】 The salt tolerant variety Jinshu 16 and salt sensitive variety Jizhangshu 12 were used as test materials. Salt stress treatments were carried out using 0%, 0.5%, 1%, and 1.5% NaCl solutions. On the 8th day, plant phenotypes and physiological and biochemical indicators were analyzed. Subsequently, a 1% salt concentration was selected for treatment, and transcriptome sequencing and bioinformatics analysis were performed on the two varieties. 【Results】 Compared to Jizhangshu 12, Jinshu 16 had lower malondialdehyde content under salt stress conditions. Transcriptome data showed significant differences in plant hormone signaling pathways and flavonoid metabolism pathways between the two varieties. 【Conclusion】 Based on the above results, several differentially expressed genes related to plant hormone signal transduction and flavonoid metabolism are screened, which provides genetic resources for improving salt tolerance in potatoes.