Abstract: 【 Objective 】This study aims to select suitable grape varieties for Turpan producing area and optimize the grape cultivars structure in the production area. 【 Methods 】Twelve grape cultivars, including Xinyu, Xinya, Qiuhongbao, Shennongjinhuanghou, Guifeimeigui, Zixiameigui, Lvzhoubaoshi, Huozhouziyu, Huozhoucuiyu, Zitianwuhe, Zicuiwuhe, and Lihongbao were used as materials. Cultivation characteristics and berry quality were compared by field investigations and laboratory analysis method in open field cultivation, and berry quality indexes were analyzed by principal component analysis.【 Results 】There were differences in phenology, growth and fruiting habits, resistance to powdery mildew and berry quality among the twelve grape cultivars. Shennongjinhuanghou and Guifeimeigui were early maturing cultivars, Xinyu and Xinya were medium maturing cultivars; Huozhoucuiyu and Huozhouziyu were late maturing cultivars, others were mid-late maturing cultivars. Xinyu, Xinya, Qiuhongbao, Huozhouziyu and Zitianwuhe had high yield with the mean yields per plant were 21.13, 30.70, 20.59, 18.22 and 25.70 kg, respectively, and all had strong or moderate growth potential. Guifeimeigui, Qiuhongbao, Huozhoucui and Xinyu were susceptible to powdery mildew, other cultivars were resistant. The cluster mass of Xinyu grape (1,243.11 g) and berry mass (14.12 g) were both the highest, soluble solid content of Guifeimeigui was the highest (22.56 ° Brix), while other cultivars had soluble solid content ranging from 18.15 to 19.82 ° Brix; Lvzhoubaoshi and Huozhoucuiyu had higher titratable acid content than other grapes, 0.55% and 0.54%, respectively. The edible rates of seeded grape cultivars Xinyu and Xinya were relatively high, 98.81% and 98.62%, respectively. The berry quality of the twelve grape cultivars was ranked as follows: Xinyu > Zitianwuhe > Xinya > Qiuhongbao > Zicuiwuhe > Guifeimeigui> Huozhouziyu > Shennongjinhuanghou > Lihongbao > Huozhoucuiyu > Zixiameigui > Lvzhoubaoshi. Cluster analysis showed that twelve grape cultivars could be divided into five categories, each type of grape had its typical characteristics. 【 Conclusion 】The cultivation characteristics and berry quality of five grape varieties: Xinyu, Xinya, Zitianwuhe, Qiuhongbao and Huozhouziyu are superior to other cultivars, which are suitable for promotion and planting in Turpan area.