Abstract: 【Objective】 To select the most suitable growth regulators and the application times of regulators in the hope of providing theoretical basis for lodging resistance and control measures of Xinjiang drip irrigation wheat. 【Methods】 Xinjong 18 were taken as the material, and different regulators as the main zones under the field drip irrigation conditions from 2021 to 2022: clear water control (CK), calcium modulate · Enodozole (A), nanocin (B), enodozole·methylpiperonium (C), antyloxyl ester (D), polylodozole (E), and in addition, the frequency of regulator application was used as the secondary zones: A total of 12 treatments were applied at rise stage (P₁) and rise stage + jointing stage (P₂) to analyze the effects of different treatments on plant height, center of gravity height, internode length, stem diameter, stem bending resistance and yield of winter wheat under drip irrigation. 【Results】 The results showed that the plant height could be controlled effectively, the center of gravity height and internode length could be reduced, and the bending resistance of the basal stems could be improved. The bending resistance of the basal stems was increased by 8.97% and 14.89% in the treatment of one-time and twice spraying of regulator. BP₂ treatment could effectively increase the effective panicle number and 1000-grain weight, and the panicle number increased significantly under CP₂ treatment. Under the premise of spraying one regulator, the yield increased by more than 10% under AP₁, BP₁ and CP₁ treatments, and under the premise of spraying two regulators, the yield increased by more than 10% under AP₂, BP₂, CP₂ and DP₂ treatments. 【Conclusion】 The plant height of AP₂ and BP₂ are relatively suitable, the stem lodging resistance is better, and the grain yield is increased greatly.