Abstract: 【Objective】 To analyze the key technology model of machine-picked cotton production in Xinjiang. 【Methods】 Data of literature review, field investigation and preliminary research were collected and summarized by statistical and literature analysis methods. 【Results】 Production technology mode of "cotton picker + supporting agronomical technology" operation; "Machine-picking, compatibility and integrity" are the important characteristics of the key technical mode of machine-picking cotton production. The key technical content of cotton picking by machine is established. 【Conclusion】 Through the implementation of the key technology mode of machine-picked cotton production, can form a large cotton picker and production of agricultural matching, so as to improve the net rate, recovery rate and quality of harvesting, reduce machine losses, and improve the quality and efficiency of machine-picked cotton production.