Abstract: 【Objective】 In order to establish a safe and efficient herbicide application method in line with the current large-scale intensive planting background, the efficacy test and safety evaluation of fenoxaprop-P-ethyl with different application methods to control weeds in corn fields were carried out. 【Methods】 Drip irrigation and plant protection UAV spraying were used to compare and analyze the actual control effect of water dripping and plant protection UAV ultra-low spraying herbicides on weeds in corn fields in Xinjiang irrigation area. 【Results】 Compared with drip irrigation, spraying 6 % flumioxazinone OD 125 mL + 90 % atrazine 62.5 mL by drone had better control effect on Chenopodium glaucum, Abutilon theophrasti, Convolvulus arvense and Echinochloa crusgalli on the 5th, 10th and 15th day after treatment, but there was no significant difference on the 30 th day.The study also found that the application of herbicides under mulched drip irrigation was significantly better than that without mulched drip irrigation, and the plant control effect and fresh weight control effect of the application of herbicides under mulched drip irrigation were 98.48 %-100 % and 99.28 %-100 %, respectively, after 30 days of treatment.The plant control effect and fresh weight control effect were only 71.60 % and 74.28 %, respectively, after 30 days of treatment of Convolvulus arvensis.In addition, different application methods did not produce obvious phytotoxicity symptoms on maize, and the yield of maize was significantly improved. 【Conclusion】 Drip application of flumioxazinone herbicide can be applied to control a variety of weeds in irrigated maize production areas in Xinjiang.