Abstract: 【Objective】 In order to screen out high-efficiency korla pear(pear for short) fire blight control agents. 【Methods】 100 billion CFU / g Bacillus velezensis DP, 1.8% octylamine acetate aqueous solution, 3% thiamphenicol microemulsion and 6% kasugamycin aqueous solution were selected for field efficacy test. 【Results】 The results showed that the control effects of high, medium and low doses of Bacillus velezensis TK2019(hereinafter referred to as Bacillus velezensis) wettable powder, 1.8% octylamine acetate, 3% benziothiazolinone microemulsion and 6% kasugamycin on pear fire blight were 71.64%, 65.22% and 51.30%, 66.69%, 56.18% and 40.30%, 66.50%, 58.19% and 41.89%, 72.28%, 60.49% and 54.22%, respectively. Among them, Bacillus velezensis wettable powder dilution concentration of 10⁷CFU / mL and 6% kasugamycin aqueous solution 500 times could significantly reduce the occurrence of pear fire blight. 【Conclusion】 The control effect of Bacillus velezensis and 6% kasugamycin on pear fire blight is significantly higher than that of the control and 1.8% caprylic acid acetate and 3% thiamethoxam microemulsion, which can better inhibit the occurrence of pear fire blight, control the number of diseased branches, improve the quality of fruit, and increase the defense enzyme activity of fragrant pear fruit. The high concentration biocontrol bacteria have better improvement effect and are safe for the growth and development of pear trees. It is suitable for popularization and application in production and promotes the sustainable, safe, high-yield and stable yield of the fragrant pear industry.