Abstract: 【Objective】 To explore the physiological response mechanism of thin-skinned melon ‘Huishu’ to salt (NaCl) stress and provide theoretical basis for melon cultivation, demonstration and promotion. 【Methods】 In this study, a substrate pot experiment was conducted to observe the changes in seedling growth, ion homeostasis, antioxidant enzyme system, and osmoregulation substances after 100 mmol/L NaCl short-term stress (5 d) and long-term stress (20 d). 【Results】 Salt stress inhibited seedling growth, destroyed ion balance and antioxidant systems. The plant height, petiole length, and leaf number decreased significantly with the prolongation of salt stress time, while the diameter, petiole diameter, and leaf thickness increased significantly with the prolongation of salt stress time. After salt stress, the Na⁺ efflux velocity decreased, the Na⁺ content increased, the K⁺ outflow velocity increased, and the K⁺ content decreased. The content of malondialdehyde increased significantly. The content of malondialdehyde significantly increased, and the activities of SOD, POD, and CAT enzymes first increased and then decreased; the content of soluble sugar, soluble protein, and free proline increased significantly. 【Conclusion】 Under salt stress, the thin-skinned melon ‘Huishu’ responds to salt stress by limiting its own growth, increasing the Na⁺ content and reducing the K⁺ content of its leaves, improving the antioxidant enzyme system, and accumulating more osmoregulation substances.