Abstract: 【Objective】 In order to understand the drug resistance of Enterococcus faecalis from pigs in Aksu area of Xinjiang to antimicrobial drugs and the carrying status of related drug resistance genes. 【Methods】 624 anal swab samples were collected from three pig farms in Aksu area and combined Enterococcus selective medium with the housekeeping gene of Enterococcus faecalis by PCR detection method that were used to isolate and identify Enterococcus faecalis. The agar dilution method was used to test the drug sensitivity of the isolated Enterococcus faecalis, and the PCR method was used to detect related drug resistance genes. 【Results】 160 strains of Enterococcus faecalis were isolated, and the isolation rate was 25.6% (160/624). The resistance rates of the isolated Enterococcus faecalis to erythromycin, tylosin, tetracycline, doxycycline, gentamicin and vornimulin all reached more than 97.0%. It is worth noting that the resistance rate of isolated Enterococcus faecalis to linezolid was 21.3% (34/160), and no vancomycin-resistant strains were found. The drug resistance spectrums of Enterococcus faecalis isolated from Aksu area were from 3 to 10, and the main spectrums are 6 (28.1%) and 8 (30.6%). 【Conclusion】 ermB, ermC, tet(K), tet(L), tet(M), aac(6')/aph(2"), lsa(E) genes were detected in all three pig farms, and the detection rates were more than 50%; the detection rate of multidrug resistant genes optrA, lsa(E) reached 25.6% (44/160), 40.0% (64/160).