Abstract: 【Objective】 To compare the effect of different concentrations of flower and fruit chemical agents on Aksu Fuji apple Yanfu 3, and then screen out the concentrations of chemical thinning agents suitable for the apple in the hope of providing a reference for controling the cost of artificial flower thinning and fruit thinning, regulating the load of fruit trees, weakening the phenomenon of small and large fruit trees, and providing reference for improving the fruit quality. 【Methods】 The orthogonal test design was used to screen the appropriate time and concentration for flower thinning and fruit thinning of Aksu Fuji apple Yanfu 3.With the use of Zithromax Flower and Zithromax Fruit remedies, 9 treatments were set up, and a water control was set up.The effect of each treatment on fruit quality was analyzed by testing the fruit quality. 【Results】 Treatment F₂ had the highest rate of thinning and single and double fruit rate of 46% and 88%, respectively, while treatment F₂ and treatment F₉ had the lowest rate of more than double fruit of 11.67% and 13.17%, respectively, and treatment F₉ had the highest single fruit rate of 58.83%.Except for treatment F₁, all the treatments had no adverse effect on fruit quality.Manual thinning required 5.5 laborers at a cost of 1,100 YUAN/667 m², while the use of chemical flower and fruit thinners required only 2 laborers at a cost of 450 YUAN/667 m² to 650 YUAN/667 m². 【Conclusion】 The thinners used in this study showed significant and stable thinning of Fuji apple trees, with treatment F₂ having the best thinning effect and treatment F₉ the second best.Except for treatment F₁, the remaining treatments had no adverse effect on fruit quality, and all nine groups of treatments reduced the number of thinning labor by 3.5, saving more than 40% of the cost.