Abstract: 【Objective】 The purpose of this study is to explore the effects of different basal fertilizers and fertilization methods on the growth and yield of winter wheat in southern Xinjiang. 【Methods】 A two-factor split zone experiment design was adopted in the field of Xindong 60 from 2019 to 2020.Two fertilization methods were set: basal application (S₁), seed application (S₂) and two basal fertilizer types: diammonium phosphate (F₁) and methoxin (F₂).The effects of different treatments on plant traits, chlorophyll content (SPAD value), leaf area index (LAI), dry matter accumulation and yield of winter wheat were studied. 【Results】 The results showed that compared with other treatments, plant height, SPAD value, leaf area index (LAI), dry matter accumulation, effective panicle number, grain yield and biomass of winter wheat were all better under F₂S₁ treatment.Compared with diammonium phosphate seed fertilizer (F₁S₂), plant height decreased, stem diameter increased, panicle length increased, and effective panicle number, grain yield and biomass of winter wheat were higher under mekoxin seed fertilizer (F₂S₂). 【Conclusion】 It can be seen that methoxin is a kind of fertilizer that can promote high yield of wheat.If winter wheat is planted with seed and fertilizer, methoxin can be used as a reference for production.