Abstract: 【Objective】 By studying the effects of different growth regulators on stem characteristics and lodging resistance of winter wheat under drip irrigation, the most suitable exogenous growth regulators for winter wheat under drip irrigation were selected to provide theoretical basis for lodging resistance and control measures of Xinjiang drip irrigation wheat. 【Methods】 Using Xindong 18 as the material, six treatments including clear water control (CK), calcium recyclate·enlobuzole (A), Aizhuangin (B), maggikin (C), antipour ester (D) and prelobuzole (E) were set up under field drip irrigation from 2021 to 2022 with different anti-lodging regulators as test factors.The effects of different treatments on plant height, center of gravity height, internode length, stem diameter, stem bending resistance and yield of winter wheat under drip irrigation were analyzed. 【Results】 The results showed that the plant height, center of gravity height and basal internode length of wheat were decreased and the stem thickness of basal internode was increased in all treatments except C.Compared with CK (water control), five treatments, A, B, C, D and E, increased the bending resistance of the second internode of wheat base by 9.44%, 19.65%, 5.20%, 16.57% and 20.00%, respectively.In terms of yield, the number of grains per ear increased by 0.97%-3.53% in the treatment of spraying regulator.The increase of 1000-particle weight was not obvious, and the 1,000-particle weight under Aizhuangsu treatment was increased by 3.93% compared with CK treatment.In terms of yield, the wheat treated with the five regulators could increase the yield by 1.10%-14.39%, and the yield increase effect was B>C>A>D>E 【Conclusion】 It was concluded that all the five exogenous growth regulators had different effects on lodging resistance traits in wheat.In addition to the improvement of plant caving resistance, in terms of yield, the effective panicle number and kernel number per panicle were increased more significantly by calcium alicyclate, enlobuzole and maggetin, and the effect of Aizonin on 1,000-grain weight was better.Compared with CK, different regulator treatments increased the yield by 1.10%-14.39%.The overall effect was better, followed by calcium tetracycline and enlobuzole.