Abstract: 【Objective】 In order to explore the water and fertilizer management plan suitable for the soilless cultivation planting mode of tomato yellow sand in facilities in southern Xinjiang. 【Methods】 Different irrigation， nitrogen fertilizer， phosphorus fertilizer and potassium fertilizer were used as experimental factors， and each factor set of five levels. The greenhouse cultivation experiment of sand culture tomato was carried out by using a half of the general rotation combination design of quaternary quadratic. The plant height， stem diameter， leaf thickness， leaf area， chlorophyll content， above ground dry weight， above ground fresh weight， underground dry weight， underground fresh weight， root activity， yield， soluble solids， soluble sugar， organic acid， sugar-acid ratio， vitamin C， lycopene and other 17 indicators were measured， and correlation analysis and principal component analysis were performed. 【Results】 （1） Medium fertilizer and low water or medium water and low fertilizer can promote the growth of plant height， stem diameter and leaf area of tomato plants， increase the accumulation of assimilation， and increase the relative content of chlorophyll and root activity. Among them， the shoot dry and fresh weight of T₉ treatment was heavier， which was 72.30 g and 616.70 g， respectively， and the root activity was larger， which was 917.09 μg / （g·h）. （2） High water and high fertilizer or low water and high fertilizer can effectively increase yield and improve tomato fruit quality. Among them， the yield of T₃ treatment was higher， which was 8 102.72 kg / 667m². The organic acid content of T₅ treatment was 0.65 %. The lycopene content of T₁₄ treatment was higher， which was 15.80 mg/kg. （3） Each index has a certain correlation with yield and quality. There was a significant negative correlation between leaf thickness and lycopene content （P< 0.05）. Organic acid content was extremely significantly correlated with leaf area （P< 0.01）. The shoot dry weight was negatively correlated with yield（P< 0.05）. There was a significant negative correlation between underground dry weight and vitamin C content （P< 0.05）. （4） Seven principal components were extracted， and the comprehensive scores of principal component factors of 17 traits were calculated by weighting the eigenvalues of the principal components. The comprehensive score of T₉ treatment was the highest， which was 0.695， and that of T₁₅ treatment was the lowest， which was 0.295. 【Conclusion】 The results showed that the T₉ treatment， that is， the irrigation amount of 310 mm， the nitrogen application rate of 570 kg / hm²， the phosphorus application rate of 438 kg / hm²， the potassium application rate of 738 kg / hm²， could effectively promote the growth and development of sand culture tomato and improve its quality.