Abstract: 【Objective】 To study the effects of DPC⁺with different concentrations of chemical topping agent on different varieties of cotton in the hope of providing a theoretical basis for the application of cotton chemical topping technology in Xinjiang. 【Method】 Three cultivars were used in this experimental, which were Xinluzao 61, Xinluzao 67, Xinluzao 72. And three concentration gradients of chemical topping agents were set, among which the low concentration was 90 g/hm²+60 ml/hm² (dactyl amine + additive); Medium concentration: 180 g/hm²+120 ml/hm²; High concentration: 270 g/hm²+180 ml/hm², with no topping and manual topping as control to study the agronomic traits, yield and fiber quality of cotton. 【Results】 Compared with no topping, chemical topping effectively controlled the agronomic traits of cotton plants. Under high concentration (270 g/hm²+180 ml/hm²), the plant height increased by 3.0~8.7cm, the number of fruit branches increased by 0.8~1.93, the plant width decreased by 1.4%~3.4%, and the number of internodes of main stem increased by 0.7~1.2 compared with the manual topping. For yield factor and fiber quality, there was no significant difference between each concentration treatment and manual topping treatment. 【Conclusion】 The use of high concentration DPC⁺ has better topping effect. The use of chemical topping with DPC⁺ can effectively replace manual topping, and the yield and quality are not reduced.