Abstract: 【 Objective 】 To evaluate the insecticidal activity of chlorfenapyr, flupirfuranone, nitenpyram, 22% flupirfenapyr SC, 17% flupirfuranone SC and 5% nitenpyram against cotton Aphis gossypii by indoor toxicity test and field efficacy test. 【 Methods 】 indoor toxicity test and field efficacy test were conducted by leaf dipping method and stem leaf spray method respectively. 【 Results 】 The results of indoor toxicity test showed that the 24 h LC₅₀ of fipronil flupyrfuranone and nitenpyram to Aphis gossypii were 2.41, 1.49 and 0.81 μg/mL respectively, and the 48 h LC₅₀ were 1.35, 0.72 and 0.32 μg/mL respectively. The results of field trials showed that 22% fipronil SC and 7% flupyrfuranone SC had good quick effect on Aphis gossypii, and the average control effect was more than 70%. 【 Conclusion 】 Fipronil, flupyrfuranone and nitenpyram can effectively control Aphis gossypii, and they are ideal substitutes for high toxic pesticides to control Aphis gossypii in cotton production.