Abstract: 【Objective】 To select the oil and medicine safflower germplasm resources high quality for both oil and medicine in Xinjiang. 【Method】 Genetic diversity analysis, variation analysis and cluster analysis were carried out on 32 oil medicine safflower germplasm resources. 【Result】 Among the germplasm resources, there were 4 in 80-90 days, 6 in 90-100 days, 16 in 100-110 days, and 6 in 110 days. Genetic diversity analysis showed that the variation range of 10 quality genetic diversity indexes was 0.37-1.29; The genetic diversity index of flower color was the highest (1.29) in quantitative characters; The highest diversity index of was oil content and oleic acid (3.47) in quality characters. 32 materials divided into 10 groups by cluster analysisIn the first category, Qinghai the main material; the second category 14 materials, the third category 3 materials, and the fourth category 3 materials, mainly from Shandong. Other materials bxy11 (Gansu), bxy1 (Xinjiang), bxy19 (Hebei), bxy3 (Jiangsu) and bxy8 (Zhejiang) classified into one group respectively. 【Conclusion】 The main germplasm resources of safflower for oil and medicine use were leaf type inversion (90.6%), common kernel shell (87.5%), cone for flower ball (84.4%) and cone for kernel (87.5%). The genetic diversity of quality characters of safflower for oil and drug use in Xinjiang was higher than that of yield characters, and the clustering of materials was not significantly related to its source, but the materials from Qinghai, Gansu, Henan and Shandong were preferred together, Xinjiang has abundant safflower oil and medicine germplasm resources, and its genetic distance is relatively long.