Abstract: 【Objective】 Comparison To compare the effect and cost of different chemical blossom thinners on Red Fuji apples, and find suitable chemicals and itsand concentration which can well regulate the load and improve quality and reduce costs in Aksu. 【Methods】 Taking the initial fruit stage and high yield stage Xinhong No. 1 as the test material, several blossom thinning treatments were evaluated, including hand-thinning (control), stone sulphur, ethephon, calcium formate, and thinner. Chemical treatments were applied when 75%-85% of center flower and 70%-85% of whole tree flower was blooming. Compared with hand thinnedthinning, the effects of thinning and cost were analyzed. 【Results】 Different concentrations of stone sulphur mixture, ethephon, calcium formate and thinner had different thinning effects. Compared with the control, there are differences in cost., The cost varies greatly. 【Conclusion】 Through the comprehensive comparison of fruit setting rate of inflorescence, fruit setting rate of flower, percentage of single fruit, empty platform rate and removal rate, the effect of the stone sulphur mixture 200 times solution in the initial fruit stage was the closest to artificial fruit thinning, and the cost was 17.08% of human labor. The effect of the stone sulphur mixture 150 times solution in the full bearing period was the closest to artificial fruit thinning, and the cost was 24..79% of human labor. The cost of chemical thinning was positively correlated with the price of thinning and tree age.