Abstract: 【Objective】 The effects of different planting densities in the surrounding areas of Manas County on different varieties of safflower harvest sites were discussed in order to provide some theoretical support for breeding methods such as safflower germplasm resource selection and breeding. 【Method】 Xinjiang safflower variety Xinhonghua No. 4 was selected as the test material, and 5 seeding densities (1.5×10⁴, 1.6×10⁴, 1.8×10⁴, 2.0×10⁴, 2.2×10⁴ plants / 667m² ) with 3 repetitions and 15 cell processing were set. Under the same growth conditions of water and fertilizer and under different planting densities, the safflower seed yield and branch number, flower ball number, seed length, seed width, seed thickness, thousand seed weight, seed oil content and fatty acid content were determined. 【Result】 There are differences in the seed characteristics of different harvesting parts. The thousand seed weight, oil content and fatty acid content of the safflower harvested in the lower part were larger than those in the middle and top, and the top harvest index was slightly higher than that of the middle harvest. Under different planting densities, there was a negative correlation between the quality of the seeds and the number of branches in different parts of the safflower. Different planting densities affected the quality and yield of safflower harvesting parts. When the planting density reached 2.0×10⁴ plants / 667m², the top, middle and lower safflower seeds had the highest grain weight and yield, and the overall quality advantage was significant. 【Conclusion】 The best planting density of Xinhonghua No. 4 in Manas County was 2.0×10⁴ plants / 667m². In the process of safflower breeding and production practice, scientific and reasonable planting density should be selected as far as possible, and the lower safflower seeds were used as propagation materials in order to achieve high quality, high yield and high efficiency.