Abstract: 【 Objective 】 To study the setting rate, fruit quality and commodity rate of the small arched shed overlaying network for prevention and treatment of late autumn replanted muskmelon virus disease in Kashgar region, identify the pathogen causing late autumn replanted muskmelon virus disease, and evaluate the resistance of breeding materials. 【 Methods 】The pest control net was removed in different periods, and the disease index of each community was calculated. RT-PCR was used to identify the infectious agents of replanted muskmelon virus disease. The disease resistance of the selected materials was identified which laid a good foundation for virus disease resistance breeding.【 Results 】The best time to remove the pest control nets in each community was before and after August 1, and the lowest disease index of the treatment community was 25,79, with an average number of results per plant was 3.1, the commodity rate was 79.3%, and the average sugar content in the fruit center was 15.8%. WMV, CMV and ZYMV were the main viruses that infected melon in late autumn in Kashgar area. The results of disease resistance identification showed that most of the selected materials were susceptible to disease, with only K-1 performing well and the disease index was 7.22, which provided material basis for the subsequent disease resistance breeding. 【 Conclusion 】The small arched shed overlaying technology can effectively prevent and control the late autumn replanted muskmelon virus disease in Kashgar region, and ensure the melon yield and quality. A virus-resistant material K-1 was screened, which provided a material basis for subsequent disease-resistant breeding.