Abstract: 【 Objective 】 The main purpose of this project is to increase cotton yield. 【 Method 】 In 2017, the optimum treatments were selected from T0 (CK non-magnetization), T1 (primary magnetization) and T2 (secondary magnetization) treatments through regular observation of cotton plant height, leaf area and other growth indicators. In 2018, different irrigation quotas (T1, T2, T3, T4, T5) were set up under the secondary magnetization treatment. The optimum irrigation quota was screened out by comparing the growth and development indexes of cotton and the water use efficiency of magnetized irrigation. 【 Result 】The results showed that the performance of cotton plants treated with T2 (secondary magnetization) was better than those treated with T1 (primary magnetization) and T0 (CK non-magnetization), and the yield of cotton was the highest, which was increased by 22.3% compared with the control. When the irrigation quota of secondary magnetization reached 3,360 m³/hm², the agronomic and yield traits of cotton reached the maximum value. At the same time, dry matter accumulation and irrigation water use efficiency were the highest. 【 Conclusion 】 The agronomic traits, yield traits and dry matter accumulation of cotton plants were greatly improved when the irrigation water was magnetized twice and the irrigation quota was 3,360 m³/hm², which not only promoted the high yield of cotton fields, but also achieved the goal of water-saving irrigation. At the same time, it provides theoretical and practical support for the development of water-saving intensive sustainable agriculture in southern Xinjiang.