Abstract: 【Objective】 To study the curative effect of American periplaneta powder on diarrhea rate, dilute stool rate, body weight, feed intake and water drinking consumption in diarrhea mice.【Method】A diarrhea model was established by intraperitoneal injection of 0.02 mL/g 3 × 10⁸ cfu/mL Escherichia coli suspension (5 d), then different doses of periplaneta powder were added to the mice feed for 10 days treatment. The body weight, feed intake, water drinking amount and the number of diarrhea mice in 2 hours were measured at 1 d, 3 d, 5 d, 7 d, 9 d, 11 d, 13 d and 15 d, respectively.【Result】Dilute stool rate and diarrhea rate were increased gradually in model group, high, middle and low dose group compared with the blank group for 1 d to 5 d, and after 3 to 5 days, the body weight, feed intake and water drinking amount of the model group, the high, middle and low dose groups were significantly different (P＜0.05). During 6 to 15 d, compared with the model group, dilute stool rate and diarrhea rate were decreased gradually in model group, high, middle and low dose group and there was significant difference in body weight in 7 d or 11 d and in water drinking amount in 9 d (P < 0.05). There were significant differences in body weight, water and feed intake in the high dose group on the 13 th day (P< 0.05), and significant differences in water drinking amount (P< 0.05) in the high dose group on the 15th day. 【Conclusion】The additive of American periplaneta powder in the mice feed could significantly reduce diarrhea rate and dilute stool rate, and increase the body weight. In terms of feed and water intake of diarrhea mice, the high dose group was significantly higher than the medium or low dose group.