Abstract: 【Objective】To developa milk beverage consists with Cyperus-derived exosomes loaded with nanoselenium and edible dock extract as functional components and then conduct animal experiments to verify its lipid-lowering effect.【Methods】The hyperlipidemia mouse model was established by feeding high-fat diet. Simvastatin was used as positive group，and high-dose，medium-dose and low-dose groups of milk beverage were set up to investigate the effects of milk beverage on body weight，organ index，serum and liver biochemical indexes，and liver histological sections.【Results】Milk beverage could inhibit the increase of body weight and liver index in high-fat mice. The contents of total cholesterol，triglyceride and low density lipoprotein cholesterol in serum and liver were decreased，and the contents of high density lipoprotein cholesterol were increased. The activity of alkaline phosphatase，alanine aminotransferase，glutamic oxalacetic aminotransferase and gamma-glutamyl transpeptidase in serum also changed. The contents of malondialdehyde and lipid peroxide in liver were decreased，too. Liver reduce glutathione content and superoxide dismutase activity increase；Hepatic tissue vacuolation decreased.【Conclusion】The results indicate that milk beverage can regulate the disorder of lipid metabolism in high-fat mice，and the medium dose has the best effect，which has provided Scientific basis for the lipid lowering effect of milk beverage.

Key words: Selenized cyperus esculentus exosome; milk beverage; lipid-lowering efficacy

摘要： 【目的】前期以硒化油莎豆外泌体、食叶草提取物为功能性成分，研究出一款乳饮料。为验证其降脂功效，特进行动物试验。【方法】通过饲喂高脂饲料建立高脂血症小鼠模型，以辛伐他汀作为阳性组，并设置乳饮料高、中、低剂量组，探究乳饮料对体重、脏器指数、血清及肝脏中相关生化指标、肝组织病理切片的影响。【结果】乳饮料可以抑制高脂模型小鼠体重的增加及肝脏指数的升高；使血清及肝脏中的总胆固醇、甘油三酯、低密度脂蛋白胆固醇含量降低，高密度脂蛋白胆固醇含量升高；血清的碱性磷酸酶、谷丙转氨酶、谷草转氨酶和γ-谷氨酰转肽酶活力变化；肝脏中丙二醛、脂质过氧化物含量降低；肝脏还原型谷胱甘肽含量及超氧化物歧化酶活力升高；肝组织空泡减少。【结论】乳饮料对高脂小鼠的脂代谢紊乱具有一定调节作用，其中剂量效果最佳，为乳饮料降脂功效提供了科学依据。

关键词: 硒化油莎豆, 外泌体乳饮料, 降脂功效