Abstract: [Objective]The experiment was designed to analyze influence of early weaning on biochemistry indicators in serum of Chinese Merino lamb.[Method]There are three groups in the experiment! former groups(Gl &G2) are experiment group with early weaning at 40 days and 60 days respectively, fed with milk replacer.While control group(G3) was fed with milk from their ewes.The indicators in serum measured include:TPi ALB,GLOB, A/G,SUN,CHOL,GLU,TG,AST, ALT,ALP.LDH, LDL,HDL,Na, K,Cl,Ca,P,Mg.[Result]The results showed that as for SUN,Gl&G2 are 4.87 mmol/L and 3.9 mmol/L higher than that of G3,significantly(P < 0.05); as for HDL , the two groups are 0.14 mmol/L and 0.1 mmol/L lower than that of G3, significantly (P < 0.05); for AST, the two groups are 17.25 U/L and 11.8 U/L lower than that of G3,significantly (P < 0.05);as for CHOL and GLU,GI is 0.33 mmol/L, and 0.51 mmol/L lower than that of G3,significantly (P<0.05);as for ALT, Na and C1,G1 is 4.22 U/L, 4.63 mmol/L and 3.14 mmol/L lower than that of G3,significantly (P < 0.05) ;as for Mg GI is 0.05 mmol/L higher than that of G3,significantly (P<0.05); as for LDH GLT is 90.14 U/L higher than that of G3,significantly(P<0.05).[Conclusion] As a result, change of SUN and HDL in serum may reflect: early weaning has effect on balance among AA and protein metabolism to some extent.Meantime, LDH, AST,and GOP are lower in serum due to early weaning ,it can enhance their ability of anti - stress.In addition, activity of ALP reflect growth speed and production performances, no significant difference of ALP between experiment groups and control group, so early weaning has not impact on growth and development of Chinese Merino lamb in this experiment.