Abstract: [Objective] This study aims to clone Carpomya vesuviana Costa odorant binding protein(CvcoOBP)and analyze expression profile of CvcoOBP in order to lay the foundation of researching CvcoOBP in Carpomya vesuviana Costa.[Method]Based on transcriptome sequencing of cephalic RNA,the study has analyzed CvcoOBP according to alignment and phylogenetic analysis.The research was also conducted into the tissue specific expression of CvcoOBP by semi-quantitative reverse transcription and polymerase chain reaction(sqRT-PCR).[Result]The study has obtained seven CvcoOBP that had been named respectively as CvcoOBP1-7(GenBank accession number: KU975053,KU975054,KU975055,KX059394,KU975056,KX059395 and KX059396).According to amino acid alignment,CvcoOBP1,CvcoOBP3,CvcoOBP4,CvcoOBP6 and CvcoOBP7 had been proved to be a family of classic OBP,which contained six highly conversed cysteine residues.CvcoOBP2 and CvcoOBP5 belonged to a family of "Minus-C",which had only four highly conversed cysteine residues.Phylogenetic analysis showed that CvcoOBP1-7 had close relationships with different OBPs.Finally,sqRT-PCR revealed that CvcoOBP1-7 could be highly expressed in abdomen,head and thorax.CvcoOBP1 and CvcoOBP2 could be also expressed in wings with relatively low expression.CvcoOBP1,CvcoOBP5 and CvcoOBP6 were also found in legs.[Conclusion]For the first time,the study obtained and analyzed seven CvcoOBP.Different CvcoOBP are various in terms of expression sites and expression quantity.The CvcoOBP1-6 separately belongs to OBP56g,OBP8a,OBP83a,OBP56h,OBP99c and OBP83ef type.