Abstract: [Objective] In order to evaluate the safety of 7.5; pyroxsulam to wheat varieties of Xinjiang and provide reference for the safe production of wheat.[Method]The effects of different physiological indexes of different wheat varieties in Xinjiang were studied by pot culture and plate method.[Result]The results indicated that there was a certain extent inhibitory effect of pyroxsulam on various physiological indexes of wheat.And the tolerance of Zhongyou 9507, Shidong 8, Shimai 15 and Jimai 22 against pyroxsulam were the strongest, while Kendong 00(2), Xindong 27, Xindong 20, Gaocheng 8901,Yannong 19,Xindong 38 and Xindong 17 were the weakest.[Conclusion]Pyroxsulam differed significantly in security among different wheat varieties of Xinjiang, so it should be used with caution for sensitive varieties.