Abstract: [Objective] To explore the best fertilization mode for Fritillaria pallidiflora Schrek in Yili area of Xinjiang.[Method]By using four factors and three levels orthogonal test design(the microbial fertilizer,phosphate fertilizer,bio organic fertilizer + organic material decomposing agent,refined organic fertilizer + organic material decomposing agent,design level 1,design level 2(2 level ×0.5)and design level 3(2 level ×1.5)a total of 9 orthogonal treatments were employed to determine the growth and soil of Fritillaria.[Result]Plant height,plant fresh weight and bulb fresh weight,soil organic matter,total nitrogen content and soil pH value were different by different fertilization amounts;With the development of Fritillaria,the soil pH under each treatment showed significantly higher value than that of the bud and flowering stages,and the regular pattern of soil organic matter and total nitrogen content of soil was not obvious;under different fertilization treatments,there was no significant difference between Fritillaria plants per 667 m2;in the same microbial fertilizer dosage,the change trend of Fritillaria yield showed no obvious regularity,treatment 8,namely,microbial fertilizer being 86 kg/667 m2,P being 18 kg/667 m2,bio organic fertilizer and organic material rot agent being 16 kg/667 m2,refined organic fertilizer and organic material and corrosion inhibitor being 60 kg/667 m2,produced the highest yield of Fritillaria 381.14 kg/667 m2;In a single microbial fertilizer dosage,the change trend of Fritillaria yield had no obvious regularity.[Conclusion]The microbial fertilizer and phosphate fertilizer as base fertilizer,combined with organic fertilizers and organic material decomposing inoculants as supplement agents,and microbial fertilizer topdressing used during the growth period of ditching can obtain high yield.