Abstract: [Objective] This experiment aims to study the relationship between Coreopsis tinctoria density, pinching times, harvest time and Coreopsis tinctoria yield and quality.[Method]The orthogonal experiment was used to determine the yield and the content of active components (total flavonoids, chlorogenic acid, total amino acid, tea polyphenol and total sugar) in different treatments of four different time periods.The comprehensive measures were screened out to select the reasonable combination of cultivation techniques.[Result]The study found that the best condition of growth and the highest yield of Coreopsis tinctoria was treatment VII (spacing of 25 cm × 40 cm, no pinching, picking every day) and treatment VI (spacing of 20 cm × 40 cm, pinching twice, picking every day).The total yield of dried flowers of Coreopsis tinctoria treatment VII was 53.52 kg/667 m2, the content of total flavonoids was about 13.51;, the content of chlorogenic acid was about 0.55;, the total amino acid content was about 10.78;, the content of tea polyphenol was about 10.27;, and the total sugar content was about 14.85;;The total yield of dried flowers of Coreopsis tinctoria treatment VI reached 50.49 kg/667 m2,the content of total flavonoids was 13.79;, the content of chlorogenic acid was about 0.57;, the total amino acid content was about 10.69;, the content of tea polyphenol was about 10.54;, and the total sugar content was about 17.04;.Although the yield of Coreopsis tinctoria treatment VI was high, considering that the two pinching times would increase the labor cost, it was not recommended as a combination of reasonable cultivation measures.Both of the yield and the quality of Coreopsis tinctoria that showed better results were the treatment I.(spacing of 15 cm×40 cm, no pinching, picking every day), whose yield was only lower than those of Coreopsis tinctoria treatment VII and VI.The yield was 45.81 kg/667 m2, the content of total flavonoids was15.46;,the content of chlorogenic acid was about 0.45;, the total amino acid content was about 12.40;, the content of tea polyphenol was about 10.65;, and the total sugar content was 14.39;.The other treatments were not prominent in plant growth, yield and quality.Treatment III (planting density of 40 cm×15 cm, pinching twice, picking once every 3 days) showed poor performance in yield and quality.[Conclusion]Different planting densities, pinching times and harvest time had a certain effect on the growth, the yield and the quality of Coreopsis tinctoria.